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MedKoo Cat#: 533083 | Name: Tanshinol borneol ester

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tanshinol borneol ester is a Novel angiogenesis stimulator, promoting multiple key steps of angiogenesis parially via Akt and MAPK signalling pathways, showing anti-ischemic and anti-atherosclerosis activities, also acting as a putative PPARγ agonist.

Chemical Structure

Tanshinol borneol ester
Tanshinol borneol ester
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 533083

Name: Tanshinol borneol ester

CAS#: N/A

Chemical Formula: C19H26O5

Exact Mass: 334.1780

Molecular Weight: 334.41

Elemental Analysis: C, 68.24; H, 7.84; O, 23.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tanshinol borneol ester
IUPAC/Chemical Name
(2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
InChi Key
HWZXIGKCWRUJPF-IRLWIRLSSA-N
InChi Code
InChI=1S/C19H26O5/c1-18(2)12-6-7-19(18,3)16(10-12)24-17(23)15(22)9-11-4-5-13(20)14(21)8-11/h4-5,8,12,15-16,20-22H,6-7,9-10H2,1-3H3/t12-,15?,16+,19?/m1/s1
SMILES Code
O=C(O[C@@H]1C(C2(C)C)(C)CC[C@]2([H])C1)C(O)CC3=CC=C(O)C(O)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liao S, Han L, Zheng X, Wang X, Zhang P, Wu J, Liu R, Fu Y, Sun J, Kang X, Liu K, Fan TP, Li S, Zheng X. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019 Sep;176(17):3143-3160. doi: 10.1111/bph.14714. Epub 2019 Jul 9. PubMed PMID: 31116880; PubMed Central PMCID: PMC6692590. 2: Wang J, Ma C, Li Q, Wang X, Yang Y, Yang L, Jiang W, Liao S, Wang S, Jia P, Zhao Y, Zheng X. Metabolite identification of tanshinol borneol ester in rats by high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. Biomed Chromatogr. 2019 Mar;33(3):e4438. doi: 10.1002/bmc.4438. Epub 2018 Dec 27. PubMed PMID: 30444936. 3: Yuan X, Fei F, Sun H, Xiao C, Zhao X, Zhang Y, Zheng X. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine. 2018 Apr 12;13:2265-2274. doi: 10.2147/IJN.S159789. eCollection 2018. PubMed PMID: 29695905; PubMed Central PMCID: PMC5905822. 4: Xu P, Hong F, Wang J, Wang J, Zhao X, Wang S, Xue T, Xu J, Zheng X, Zhai Y. DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2690-2701. doi: 10.1016/j.bbagen.2017.07.013. Epub 2017 Jul 20. PubMed PMID: 28736228. 5: Wang X, Yang J, Yuan H, Liu XL, Li Y, Jia P, Zheng XH, Zheng XP. [Protective effect and related mechanism of tanshinol borneol ester on homocysteine induced rat bone marrow mesenchymal stem cells damage]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Feb 24;45(2):130-136. doi: 10.3760/cma.j.issn.0253-3758.2017.02.012. Chinese. PubMed PMID: 28260319. 6: Jia P, Wang S, Xiao C, Yang L, Chen Y, Jiang W, Zheng X, Zhao G, Zang W, Zheng X. The anti-atherosclerotic effect of tanshinol borneol ester using fecal metabolomics based on liquid chromatography-mass spectrometry. Analyst. 2016 Feb 7;141(3):1112-20. doi: 10.1039/c5an01970b. Epub 2015 Dec 22. PubMed PMID: 26689835. 7: Nie F, Bu M, Wu L, Zheng J. An ultrasensitive chemiluminescent method for the tanshinol borneol ester determination and its pharmacokinetic analysis. Luminescence. 2014 Mar;29(2):147-50. doi: 10.1002/bio.2519. Epub 2013 May 17. PubMed PMID: 23681963. 8: Liu D, Gao Y, Wang H, Zi J, Huang H, Ji J, Zhou R, Nan Y, Wang S, Zheng X, Zhu J, Cui Y, Chen C. Evaluation of the effects of cytochrome P450 nonsynonymous single-nucleotide polymorphisms on tanshinol borneol ester metabolism and inhibition potential. Drug Metab Dispos. 2010 Dec;38(12):2259-65. doi: 10.1124/dmd.110.034439. Epub 2010 Aug 24. PubMed PMID: 20736323. 9: Liu D, Zheng X, Tang Y, Zi J, Nan Y, Wang S, Xiao C, Zhu J, Chen C. Metabolism of tanshinol borneol ester in rat and human liver microsomes. Drug Metab Dispos. 2010 Sep;38(9):1464-70. doi: 10.1124/dmd.110.033381. Epub 2010 Jun 3. PubMed PMID: 20522662.

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