G140 | CAS#N/A

MedKoo Cat#: 533080 | Name: G140

Description:

WARNING: This product is for research use only, not for human or veterinary use.

G140 is a Novel potent cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 14 nM and 442 nM for h-cGAS and m-cGAS, respectively).

Chemical Structure

G140

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 533080

Name: G140

CAS#: N/A

Chemical Formula: C17H16Cl2N4O2

Exact Mass: 378.0650

Molecular Weight: 379.24

Elemental Analysis: C, 53.84; H, 4.25; Cl, 18.70; N, 14.77; O, 8.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

G140; G-140; G 140

IUPAC/Chemical Name

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one

InChi Key

NVPFAXHXXODQRO-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3

SMILES Code

O=C(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)CO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 379.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rhee SY, Grant PM, Tzou PL, Barrow G, Harrigan PR, Ioannidis JPA, Shafer RW. A systematic review of the genetic mechanisms of dolutegravir resistance. J Antimicrob Chemother. 2019 Nov 1;74(11):3135-3149. doi: 10.1093/jac/dkz256. PubMed PMID: 31280314; PubMed Central PMCID: PMC6798839. 2: Ferrari D, Spagnuolo V, Manca M, Bigoloni A, Muccini C, Banfi G, Locatelli M, Castagna A. Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients. Antivir Ther. 2019;24(1):69-72. doi: 10.3851/IMP3275. PubMed PMID: 30353884. 3: Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157. doi: 10.1152/ajpgi.00288.2017. Epub 2018 Mar 22. PubMed PMID: 29565640; PubMed Central PMCID: PMC6109711. 4: Azuma K, Umezu T, Imanishi S, Asano M, Yoshizawa S, Katagiri S, Ohyashiki K, Ohyashiki JH. Genetic variations of bone marrow mesenchymal stromal cells derived from acute leukemia and myelodysplastic syndrome by targeted deep sequencing. Leuk Res. 2017 Nov;62:23-28. doi: 10.1016/j.leukres.2017.09.008. Epub 2017 Sep 21. PubMed PMID: 28964959. 5: Xiao L, Ding M, Zhang Y, Chordia M, Pan D, Shimer A, Shen F, Glover D, Jin L, Li X. A Novel Modality for Functional Imaging in Acute Intervertebral Disk Herniation via Tracking Leukocyte Infiltration. Mol Imaging Biol. 2017 Oct;19(5):703-713. doi: 10.1007/s11307-016-1038-6. PubMed PMID: 28050750; PubMed Central PMCID: PMC5495619. 6: Soulié C, Assoumou L, Darty M, Rodriguez C, Donati F, Sayon S, Peytavin G, Valantin MA, Caby F, Schneider L, Canestri A, Costagliola D, Katlama C, Calvez V, Marcelin AG; ROCnRAL ANRS-157 Study Group. Virological factors associated with outcome of dual maraviroc/raltegravir therapy (ANRS-157 trial). J Antimicrob Chemother. 2015 Dec;70(12):3339-44. doi: 10.1093/jac/dkv280. Epub 2015 Sep 22. PubMed PMID: 26396157. 7: Zou J, Lee le T, Wang QY, Xie X, Lu S, Yau YH, Yuan Z, Geifman Shochat S, Kang C, Lescar J, Shi PY. Mapping the Interactions between the NS4B and NS3 proteins of dengue virus. J Virol. 2015 Apr;89(7):3471-83. doi: 10.1128/JVI.03454-14. Epub 2015 Jan 14. PubMed PMID: 25589636; PubMed Central PMCID: PMC4403433. 8: Koay LC, Rigby RJ, Wright KL. Cannabinoid-induced autophagy regulates suppressor of cytokine signaling-3 in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G140-8. doi: 10.1152/ajpgi.00317.2013. Epub 2014 May 15. PubMed PMID: 24833710; PubMed Central PMCID: PMC4101681. 9: Kang JJ, Shu L, Park JL, Shayman JA, Bodary PF. Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G140-6. doi: 10.1152/ajpgi.00185.2013. Epub 2013 Nov 14. PubMed PMID: 24232002; PubMed Central PMCID: PMC3920075. 10: Osorio JG, Muzzio FJ. Effects of powder flow properties on capsule filling weight uniformity. Drug Dev Ind Pharm. 2013 Sep;39(9):1464-75. doi: 10.3109/03639045.2012.728227. PubMed PMID: 23902366. 11: Sreeraman R, Vijayakumar S, Chen AM. Correlation of radiation treatment interruptions with psychiatric disease and performance status in head and neck cancer patients. Support Care Cancer. 2013 Dec;21(12):3301-6. doi: 10.1007/s00520-013-1907-3. Epub 2013 Jul 28. PubMed PMID: 23892904. 12: Juárez O, Neehaul Y, Turk E, Chahboun N, DeMicco JM, Hellwig P, Barquera B. The role of glycine residues 140 and 141 of subunit B in the functional ubiquinone binding site of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae. J Biol Chem. 2012 Jul 20;287(30):25678-85. doi: 10.1074/jbc.M112.366088. Epub 2012 May 29. PubMed PMID: 22645140; PubMed Central PMCID: PMC3408181. 13: Chen AM, Marsano J, Perks J, Farwell G, Luu Q, Donald PJ, Purdy JA. Comparison of IMRT techniques in the radiotherapeutic management of head and neck cancer: is tomotherapy "better" than step-and-shoot IMRT? Technol Cancer Res Treat. 2011 Apr;10(2):171-7. PubMed PMID: 21381795. 14: Métifiot M, Marchand C, Maddali K, Pommier Y. Resistance to integrase inhibitors. Viruses. 2010 Jun 25;2(7):1347-66. PubMed PMID: 20706558; PubMed Central PMCID: PMC2920056. 15: Chen A, Lee N, Yang C, Liu T, Narayan S, Vijayakumar S, Purdy J. Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: dosimetric analysis incorporating quality assurance guidelines from RTOG 0225. Technol Cancer Res Treat. 2010 Jun;9(3):291-8. PubMed PMID: 20441239. 16: Corn BW, Wang M, Fox S, Michalski J, Purdy J, Simpson J, Kresl J, Curran WJ Jr, Diaz A, Mehta M, Movsas B. Health related quality of life and cognitive status in patients with glioblastoma multiforme receiving escalating doses of conformal three dimensional radiation on RTOG 98-03. J Neurooncol. 2009 Nov;95(2):247-257. doi: 10.1007/s11060-009-9923-3. Epub 2009 Jun 16. PubMed PMID: 19533025; PubMed Central PMCID: PMC2864919. 17: Delelis O, Malet I, Na L, Tchertanov L, Calvez V, Marcelin AG, Subra F, Deprez E, Mouscadet JF. The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation. Nucleic Acids Res. 2009 Mar;37(4):1193-201. doi: 10.1093/nar/gkn1050. Epub 2009 Jan 7. PubMed PMID: 19129221; PubMed Central PMCID: PMC2651800. 18: Garrison AP, Dekaney CM, von Allmen DC, Lund PK, Henning SJ, Helmrath MA. Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G643-50. doi: 10.1152/ajpgi.90588.2008. Epub 2008 Dec 31. PubMed PMID: 19118113; PubMed Central PMCID: PMC2660180. 19: Stockx EM, Anderson CR, Murphy SM, Cooke IR, Berger PJ. The development of descending projections from the brainstem to the spinal cord in the fetal sheep. BMC Neurosci. 2007 Jun 18;8:40. PubMed PMID: 17577416; PubMed Central PMCID: PMC1919385. 20: Stockx EM, Anderson CR, Murphy SM, Cooke IR, Berger PJ. A map of the major nuclei of the fetal sheep brainstem. Brain Res Bull. 2007 Jan 9;71(4):355-64. Epub 2006 Oct 27. PubMed PMID: 17208652.