MedKoo Cat#: 555686 | Name: BAY-298

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAY-298 is a Potent and Selective Antagonist of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. BAY-298 is the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo.

Chemical Structure

BAY-298
BAY-298
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555686

Name: BAY-298

CAS#: Unknown

Chemical Formula: C27H21ClFN3O2

Exact Mass: 473.1306

Molecular Weight: 473.93

Elemental Analysis: C, 68.43; H, 4.47; Cl, 7.48; F, 4.01; N, 8.87; O, 6.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BAY-298; BAY 298; BAY298;
IUPAC/Chemical Name
(5S)-5-(4-Chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide
InChi Key
FMQWOAKTQPLQBR-SANMLTNESA-N
InChi Code
InChI=1S/C27H21ClFN3O2/c28-19-5-3-18(4-6-19)26-24-2-1-16-30-25(24)15-17-32(26)27(33)31-21-9-13-23(14-10-21)34-22-11-7-20(29)8-12-22/h1-14,16,26H,15,17H2,(H,31,33)/t26-/m0/s1
SMILES Code
O=C(N1[C@@H](C2=CC=C(Cl)C=C2)C3=C(N=CC=C3)CC1)NC4=CC=C(OC5=CC=C(F)C=C5)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo Lars WortmannBernhard LindenthalPeter MuhnAlexander WalterReinhard NubbemeyerDieter HeldmannLothar SobekFederica MorandiAnna K. SchreyDieter MoosmayerJudith GüntherJoachim KuhnkeMarcus KoppitzUlrich LueckingUlrike RoehnMartina SchäferKatrin Nowak-ReppelRonald KuehneHilmar WeinmannGernot Langer Journal of Medicinal Chemistry, Just AcceptedSubscribed Access Publication Date (Web):October 31, 2019 DOI: 10.1021/acs.jmedchem.9b01382