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MedKoo Cat#: 585220 | Name: ST 91

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ST 91 is a clonidine analogue that does not cross the blood-brain barrier and stimulates atrial natriuretic peptide release.

Chemical Structure

ST 91
CAS#4751-48-8

Theoretical Analysis

MedKoo Cat#: 585220

Name: ST 91

CAS#: 4751-48-8

Chemical Formula: C13H19N3

Exact Mass: 217.1579

Molecular Weight: 217.32

Elemental Analysis: C, 71.85; H, 8.81; N, 19.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ST 91; ST91; ST-91
IUPAC/Chemical Name
N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine
InChi Key
IALHTUPVRAQZFI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19N3/c1-3-10-6-5-7-11(4-2)12(10)16-13-14-8-9-15-13/h5-7H,3-4,8-9H2,1-2H3,(H2,14,15,16)
SMILES Code
CCC1=C(NC2=NCCN2)C(CC)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 217.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Demczuk W, Sidhu S, Unemo M, Whiley DM, Allen VG, Dillon JR, Cole M, Seah C, Trembizki E, Trees DL, Kersh EN, Abrams AJ, de Vries HJC, van Dam AP, Medina I, Bharat A, Mulvey MR, Van Domselaar G, Martin I. Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains. J Clin Microbiol. 2017 May;55(5):1454-1468. doi: 10.1128/JCM.00100-17. Epub 2017 Feb 22. PubMed PMID: 28228492; PubMed Central PMCID: PMC5405263. 2: Scriabine A, Sweet CS, Ludden CT, Stavorski JM, Wenger HC, Bohidar NR. Some cardiovascular effects of ST-91 and clonidine. Eur J Pharmacol. 1977 Jun 15;43(4):333-41. PubMed PMID: 18355. 3: Kehne JH, Cassella JV, Aghajanian GK, Tallman JF, Davis M. Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91. Brain Res. 1987 Mar 17;406(1-2):87-92. PubMed PMID: 3032362. 4: Nazarian A, Christianson CA, Hua XY, Yaksh TL. Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. Br J Pharmacol. 2008 Dec;155(7):1117-26. doi: 10.1038/bjp.2008.341. Epub 2008 Sep 1. PubMed PMID: 18846040; PubMed Central PMCID: PMC2597249. 5: Takano Y, Yaksh TL. Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: spinal alpha 2 adrenoceptor subtypes and intrinsic activity. J Pharmacol Exp Ther. 1993 Jan;264(1):327-35. PubMed PMID: 8093729. 6: Graham BA, Hammond DL, Proudfit HK. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain. 2000 Mar;85(1-2):135-43. PubMed PMID: 10692612. 7: Monasky MS, Zinsmeister AR, Stevens CW, Yaksh TL. Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance. J Pharmacol Exp Ther. 1990 Aug;254(2):383-92. PubMed PMID: 1974633. 8: Takano Y, Yaksh TL. Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. J Pharmacol Exp Ther. 1991 Aug;258(2):438-46. PubMed PMID: 1678011. 9: Dowlatshahi P, Yaksh TL. Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesth Analg. 1997 Jan;84(1):133-8. PubMed PMID: 8989014. 10: de Melo Gagliato D, Cortes J, Curigliano G, Loi S, Denkert C, Perez-Garcia J, Holgado E. Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice. Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):527-537. doi: 10.1016/j.bbcan.2017.10.003. Epub 2017 Oct 20. Review. PubMed PMID: 29061314. 11: Gutkowska J, Mukaddam-Daher S, Tremblay J. The peripheral action of clonidine analog ST-91: involvement of atrial natriuretic factor. J Pharmacol Exp Ther. 1997 May;281(2):670-6. PubMed PMID: 9152372. 12: Celly CS, McDonell WN, Black WD. Cardiopulmonary effects of the alpha2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J Pharmacol Exp Ther. 1999 May;289(2):712-20. PubMed PMID: 10215644. 13: Berg T. Angiotensin AT1 - α2C-Adrenoceptor Interaction Disturbs α2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats. Front Neurol. 2013 Jun 10;4:70. doi: 10.3389/fneur.2013.00070. eCollection 2013. PubMed PMID: 23772221; PubMed Central PMCID: PMC3677154. 14: Carvalho-Castro GA, Silva JR, Paiva LV, Custódio DAC, Moreira RO, Mian GF, Prado IA, Chalfun-Junior A, Costa GM. Molecular epidemiology of Streptococcus agalactiae isolated from mastitis in Brazilian dairy herds. Braz J Microbiol. 2017 Jul - Sep;48(3):551-559. doi: 10.1016/j.bjm.2017.02.004. Epub 2017 Feb 16. PubMed PMID: 28256391; PubMed Central PMCID: PMC5498452. 15: Widdop RE. The effects of B-HT 920 and St 91 on venous haemodynamics in cats. J Pharm Pharmacol. 1989 Jan;41(1):55-6. PubMed PMID: 2565967. 16: Mukaddam-Daher S, Lambert C, Gutkowska J. Clonidine and ST-91 may activate imidazoline binding sites in the heart to release atrial natriuretic peptide. Hypertension. 1997 Jul;30(1 Pt 1):83-7. PubMed PMID: 9231825. 17: McLennan PL, Bentley GA. Effects of prazosin and piperoxan on central cardiovascular actions of St 91 in cats. Eur J Pharmacol. 1982 Dec 17;86(1):19-26. PubMed PMID: 7160431. 18: Saeki S, Yaksh TL. Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli. J Pharmacol Exp Ther. 1992 Feb;260(2):795-802. PubMed PMID: 1346645. 19: Kästner SB. A2-agonists in sheep: a review. Vet Anaesth Analg. 2006 Mar;33(2):79-96. Review. PubMed PMID: 16475998. 20: Lang IM, Sarna SK. The role of adrenergic receptors in the initiation of vomiting and its gastrointestinal motor correlates. J Pharmacol Exp Ther. 1992 Oct;263(1):395-403. PubMed PMID: 1357160.