APH199 is a G Protein-Biased Dopamine D4 Receptor Agonist with High Subtype Selectivity ([up to Ki(D4.4) = 0.25 nM, D2L/D4.4 = 320, D3/D4.4 = 710). APH199 was found to act as a full agonist at the D4 receptor showing significant bias toward G protein activation over β-arrestin recruitment in comparison to quinpirole.
MedKoo Cat#: 555684
Name: APH199
CAS#: Unknown
Chemical Formula: C28H35N5O2
Exact Mass: 473.2791
Molecular Weight: 473.62
Elemental Analysis: C, 71.01; H, 7.45; N, 14.79; O, 6.76
The following data is based on the product molecular weight 473.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
