MG-277 is a Molecular Glue. MG-277 is not a PROTAC MDM2 degrader but instead works as a molecular glue, inducing degradation of a translation termination factor, GSPT1 to achieve its potent anticancer activity. MG-277 is a New Analogue of MD-222, a Bona fide PROTAC MDM2 Degrader. MG-277 Displays High Potencies in Inhibition of Cell Growth in Cancer Cell Lines with Different p53 Status, in Contrast to the Bona fide PROTAC MDM2 Degrader MD-222.
MedKoo Cat#: 555678
Name: MG-277
CAS#: Unknown
Chemical Formula: C41H42Cl2FN5O5
Exact Mass: 773.2547
Molecular Weight: 774.72
Elemental Analysis: C, 63.57; H, 5.46; Cl, 9.15; F, 2.45; N, 9.04; O, 10.33
The following data is based on the product molecular weight 774.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
