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MedKoo Cat#: 555673 | Name: DC-260126
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DC-260126 is a FFA1 (GPR40) antagonist.

Chemical Structure

DC-260126
DC-260126
CAS#346692-04-4

Theoretical Analysis

MedKoo Cat#: 555673

Name: DC-260126

CAS#: 346692-04-4

Chemical Formula: C16H18FNO2S

Exact Mass: 307.1042

Molecular Weight: 307.38

Elemental Analysis: C, 62.52; H, 5.90; F, 6.18; N, 4.56; O, 10.41; S, 10.43

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
DC 260126; DC-260126; DC260126;
IUPAC/Chemical Name
N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
InChi Key
CNGHPXKWPGIDSK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
SMILES Code
O=S(C1=CC=C(F)C=C1)(NC2=CC=C(CCCC)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
DC260126 is a potent antagonist of GPR40 (FFAR1).
In vitro activity:
DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 β cells from palmitate-induced ER stress and apoptosis. Reference: J Cell Biochem. 2012 Apr;113(4):1152-8. https://pubmed.ncbi.nlm.nih.gov/22275065/
In vivo activity:
Fig. 5A showed an obvious increase in number of apoptotic β-cells in the islets of vehicle treated db/db mice, which indicated that with the development of hyperglycemia, the apoptotic pancreatic β-cells of db/db mice from age of 9-week-old increased significantly. However, treatment of DC260126 reduced the number of apoptotic β-cells significantly (Fig. 5B), which suggested that long-term administration of DC260126 could prevent pancreatic β-cells apoptosis. Reference: PLoS One. 2013 Jun 11;8(6):e66744. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679087/
Solvent mg/mL mM
Solubility
DMSO 50.3 163.48
DMF 30.0 97.60
Ethanol 65.4 212.67
Ethanol:PBS (pH 7.2) (1:3) 0.3 0.81
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 307.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis. J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. Erratum in: J Cell Biochem. 2013 May;114(5):1216. PMID: 22275065. 2. Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One. 2013 Jun 11;8(6):e66744. doi: 10.1371/journal.pone.0066744. PMID: 23776696; PMCID: PMC3679087. 3. Zhang X, Yan G, Li Y, Zhu W, Wang H. DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed Pharmacother. 2010 Nov;64(9):647-51. doi: 10.1016/j.biopha.2010.06.008. PMID: 20888730.
In vitro protocol:
1. Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis. J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. Erratum in: J Cell Biochem. 2013 May;114(5):1216. PMID: 22275065.
In vivo protocol:
1. Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One. 2013 Jun 11;8(6):e66744. doi: 10.1371/journal.pone.0066744. PMID: 23776696; PMCID: PMC3679087. 2. Zhang X, Yan G, Li Y, Zhu W, Wang H. DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed Pharmacother. 2010 Nov;64(9):647-51. doi: 10.1016/j.biopha.2010.06.008. PMID: 20888730.
1: Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H. DC260126: a small- molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One. 2013 Jun 11;8(6):e66744. doi: 10.1371/journal.pone.0066744. PMID: 23776696; PMCID: PMC3679087. 2: Zhang X, Yan G, Li Y, Zhu W, Wang H. DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed Pharmacother. 2010 Nov;64(9):647-51. doi: 10.1016/j.biopha.2010.06.008. PMID: 20888730. 3: Lin X, Wang L, Lu X, Zhang Y, Zheng R, Chen R, Zhang W. Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice. Respir Res. 2023 Feb 17;24(1):56. doi: 10.1186/s12931-023-02361-1. PMID: 36803977; PMCID: PMC9938616. 4: Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis. J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. Erratum in: J Cell Biochem. 2013 May;114(5):1216. PMID: 22275065. 5: Carullo G, Perri M, Manetti F, Aiello F, Caroleo MC, Cione E. Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1761-1764. doi: 10.1016/j.bmcl.2019.05.018. Epub 2019 May 13. PMID: 31104992. 6: Park Y, Ku L, Lim JW, Kim H. Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells. Genes Nutr. 2020 Mar 23;15(1):6. doi: 10.1186/s12263-020-00664-2. PMID: 32293245; PMCID: PMC7092610. 7: Pessina F, Casini I, Gamberucci A, Carullo G, Signorini C, Brizzi A, Aiello F, Aloisi AM, Pieretti S. Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist. Int J Mol Sci. 2024 Oct 30;25(21):11635. doi: 10.3390/ijms252111635. PMID: 39519187; PMCID: PMC11546106. 8: Kato S, Utsumi D, Matsumoto K. G protein-coupled receptor 40 activation ameliorates dextran sulfate sodium-induced colitis in mice via the upregulation of glucagon-likepeptide-2. J Pharmacol Sci. 2019 Jun;140(2):144-152. doi: 10.1016/j.jphs.2019.05.003. Epub 2019 May 22. PMID: 31242961. 9: Towers AE, Oelschlager ML, Juda MB, Jain S, Gainey SJ, Freund GG. HFD refeeding in mice after fasting impairs learning by activating caspase-1 in the brain. Metabolism. 2020 Jan;102:153989. doi: 10.1016/j.metabol.2019.153989. Epub 2019 Nov 5. PMID: 31697963; PMCID: PMC6906226. 10: Hu H, He LY, Gong Z, Li N, Lu YN, Zhai QW, Liu H, Jiang HL, Zhu WL, Wang HY. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009 Dec 18;390(3):557-63. doi: 10.1016/j.bbrc.2009.10.004. Epub 2009 Oct 8. PMID: 19818732.