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MedKoo Cat#: 585193 | Name: Pirprofen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pirprofen is an anti-inflammatory agent used in therapy of rheumatoid arthritis and a prostaglandin synthetase inhibitor.

Chemical Structure

Pirprofen
Pirprofen
CAS#31793-07-4

Theoretical Analysis

MedKoo Cat#: 585193

Name: Pirprofen

CAS#: 31793-07-4

Chemical Formula: C13H14ClNO2

Exact Mass: 251.0713

Molecular Weight: 251.71

Elemental Analysis: C, 62.03; H, 5.61; Cl, 14.08; N, 5.56; O, 12.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pirprofen; Rengasil; SU 21524; SU21524; SU-21524
IUPAC/Chemical Name
Benzeneacetic acid, 3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-alpha-methyl-
InChi Key
PIDSZXPFGCURGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14ClNO2/c1-9(13(16)17)10-4-5-12(11(14)8-10)15-6-2-3-7-15/h2-5,8-9H,6-7H2,1H3,(H,16,17)
SMILES Code
O=C(O)C(C)C1=CC=C(N2CC=CC2)C(Cl)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 251.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dionne RE, Weber SS. Pirprofen. Drug Intell Clin Pharm. 1983 Dec;17(12):894-7. Review. PubMed PMID: 6360612. 2: Ku EC, Wasvary JM. Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme. Biochim Biophys Acta. 1975 Apr 19;384(2):360-8. PubMed PMID: 804924. 3: Kinnunen E, Erkinjuntti T, Färkkilä M, Palomäki H, Porras J, Teirmaa H, Freudenthal Y, Andersson P. Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Cephalalgia. 1988 Sep;8(3):175-9. PubMed PMID: 3143482. 4: Gerardin A, Luders RC, Wagner WE Jr. Absorption kinetics and model characteristics of orally administered pirprofen. J Pharmacokinet Biopharm. 1983 Aug;11(4):425-33. PubMed PMID: 6668551. 5: Todd PA, Beresford R. Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1986 Dec;32(6):509-37. Review. PubMed PMID: 3539573. 6: Geneve J, Hayat-Bonan B, Labbe G, Degott C, Letteron P, Freneaux E, Dinh TL, Larrey D, Pessayre D. Inhibition of mitochondrial beta-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug. J Pharmacol Exp Ther. 1987 Sep;242(3):1133-7. PubMed PMID: 3116197. 7: Saykaly RJ, Love DW, Simon JA, DeGuzmann R, Gabovitch E. Comparative efficacy of pirprofen and aspirin in rheumatoid arthritis. J Clin Pharmacol. 1979 Jan;19(1):56-63. PubMed PMID: 368086. 8: Baumgartner H, Kuttelwascher M, McCaskey D, Winters L. The comparative efficacy of naproxen sodium and pirprofen in the treatment of post-operative pain. J Int Med Res. 1987 May-Jun;15(3):179-87. PubMed PMID: 3301458. 9: Magdalou J, Chajes V, Lafaurie C, Siest G. Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes. Drug Metab Dispos. 1990 Sep-Oct;18(5):692-7. PubMed PMID: 1981722. 10: Montrone F, Petrillo M, Caruso I, Bianchi Porro G. A comparison of severe gastric damage as a result of pirprofen and naproxen treatment in rheumatoid arthritis: a controlled endoscopic study. J Intern Med. 1994 Aug;236(2):153-9. PubMed PMID: 8046314. 11: Pfaffenrath V, Scherzer S. Analgesics and NSAIDs in the treatment of the acute migraine attack. Cephalalgia. 1995 Oct;15 Suppl 15:14-20. Review. PubMed PMID: 8749241. 12: Degen PH, Schweizer A, Sioufi A. Determination of pirprofen in biological material by gas-liquid chromatography with nitrogen-specific and electron-capture detection. J Chromatogr. 1984 May 4;290:33-43. PubMed PMID: 6736165. 13: Liang WT, Brocks DR, Jamali F. Stereospecific high-performance liquid chromatographic assay of pirprofen enantiomers in rat plasma and urine. J Chromatogr. 1992 Jun 10;577(2):317-24. PubMed PMID: 1400762. 14: Fedele L, Marchini M, Acaia B, Garagiola U, Tiengo M. Dynamics and significance of placebo response in primary dysmenorrhea. Pain. 1989 Jan;36(1):43-7. PubMed PMID: 2919094. 15: Crouzet J. [Treatment of extra-articular rheumatism with pirprofen]. Nouv Presse Med. 1982 Aug 28;11(33):2503-5. French. PubMed PMID: 6752876. 16: Singleton CM, Wild JH. A double-blind comparison of aspirin and pirprofen in the treatment of rheumatoid arthritis. J Rheumatol. 1980 Nov-Dec;7(6):865-70. PubMed PMID: 7009859. 17: Saggio F, Maresca V, Monza GC. Pirprofen in acute ocular inflammation: a controlled study. Curr Med Res Opin. 1985;9(10):697-700. PubMed PMID: 3907989. 18: Capsoni F, Venegoni E, Minonzio F, Ongari AM, Maresca V, Zanussi C. Effect of pirprofen on polymorphonuclear leukocyte functions in vitro. Int J Tissue React. 1987;9(6):465-70. PubMed PMID: 3448026. 19: Luders RC, Maggio-Cavaliere MB, Egger H, Gum OB, Resnick O, Bartlett F, Gaito MJ, Soo A, Li C. Disposition of pirprofen, a new anti-inflammatory drug. Clin Pharmacol Ther. 1977 Jun;21(6):721-30. PubMed PMID: 862311. 20: Guidotti M, Zanasi S, Garagiola U. Pirprofen in the treatment of migraine and episodic headache attacks: a placebo-controlled crossover clinical trial. J Int Med Res. 1989 Jan-Feb;17(1):48-54. PubMed PMID: 2651177.