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MedKoo Cat#: 585191 | Name: Bemetizide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bemetizide is a diuretic agent.

Chemical Structure

Bemetizide
Bemetizide
CAS#1824-52-8

Theoretical Analysis

MedKoo Cat#: 585191

Name: Bemetizide

CAS#: 1824-52-8

Chemical Formula: C15H16ClN3O4S2

Exact Mass: 401.0271

Molecular Weight: 401.88

Elemental Analysis: C, 44.83; H, 4.01; Cl, 8.82; N, 10.46; O, 15.92; S, 15.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SU 7078; SU7078; SU-7078; DIU 60; Pertensosanol; Bemetizide
IUPAC/Chemical Name
6-Chloro-3,4-dihydro-3-(alpha-methylbenzyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
InChi Key
PYVUMAGVCSQCBD-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16ClN3O4S2/c1-9(10-5-3-2-4-6-10)15-18-12-7-11(16)13(24(17,20)21)8-14(12)25(22,23)19-15/h2-9,15,18-19H,1H3,(H2,17,20,21)
SMILES Code
O=S(C1=C(Cl)C=C(C2=C1)NC(C(C)C3=CC=CC=C3)NS2(=O)=O)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Düsing R, Nicolas V, Glatte B, Glänzer K, Kipnowski J, Kramer HJ. Interaction of bemetizide and indomethacin in the kidney. Br J Clin Pharmacol. 1983 Oct;16(4):377-83. PubMed PMID: 6578835; PubMed Central PMCID: PMC1428027. 2: Mühlberg W, Mutschler E, Hofner A, Spahn-Langguth H, Arnold O. The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study. Arch Gerontol Geriatr. 2001 Jun;32(3):265-73. PubMed PMID: 11395172. 3: Knauf H, Cawello W, Schmidt G, Mutschler E. The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate. Eur J Clin Pharmacol. 1994;46(1):9-13. PubMed PMID: 8005195. 4: Hornung R, Keiso H, Raftery EB, Whittington JR. Placebo-controlled trial of a combination of bemetizide and triamterene ('Hypertane') in mild or moderate hypertension. Curr Med Res Opin. 1983;8(6):425-33. PubMed PMID: 6342957. 5: Selvaag E, Anholt H, Moan J, Thune P. Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics. J Photochem Photobiol B. 1997 Mar;38(1):88-93. PubMed PMID: 9134756. 6: KLEPZIG H, REICHERT F. [ON THE TREATMENT OF POSTTHROMBOTIC EDEMA WITH DEHYDROSANOL]. Med Welt. 1965 Jan 23;18:215-8. German. PubMed PMID: 14269680. 7: Neumann D, Schmidt G. [Diuretic and saluretic effects of bemetizide and triamterene compared to those of their combination (author's transl)]. Arzneimittelforschung. 1977;27(3):559-62. German. PubMed PMID: 577422. 8: Wray R, Benton KG, Whitehill D, Wright B, Weener W, Whittington JR. Comparative clinical trial of bemetizide/triamterene and cyclopenthiazide/potassium chloride combinations in patients with mild to moderate hypertension. Curr Med Res Opin. 1983;8(9):665-74. PubMed PMID: 6365467. 9: Lederle RM, Klaus D. [Treatment of hypertension with bupranolol, bemetizide and triamterene]. Dtsch Med Wochenschr. 1982 Oct 22;107(42):1587-91. German. PubMed PMID: 7128471. 10: Piper C, Cawello W, Bonn R, Weber E. [Pharmacodynamics and pharmacokinetics of bemetizid in comparison with hydrochlorothiazide. A controlled human pharmacologic study of acute effects]. Arzneimittelforschung. 1983;33(7):988-96. German. PubMed PMID: 6684935. 11: Brodie RR, Chasseaud LF, Darragh A, Taylor T, Walmsley LM. Bioavailability of bemetizide and triamterene from a combination formulation. Biopharm Drug Dispos. 1982 Oct-Dec;3(4):361-70. PubMed PMID: 7159690. 12: Felix W, Manz M. [Effect of triamterene and bemetizide on transcapillary water metabolism]. Med Welt. 1975 May 23;26(21):1043-50. German. PubMed PMID: 1143071. 13: Selvaag E, Anholt H, Moan J, Thune P. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. PubMed PMID: 8884891. 14: Brodie RR, Chasseaud LF, Taylor T. Determination of the thiazide diuretic bemetizide in the plasma and urine of humans by high-performance liquid chromatography. J Chromatogr. 1978 Jul 1;146(1):152-6. PubMed PMID: 670351. 15: Schäfer GE, Werner E. [The effect of bemetizide-triamterene on the serum and whole body potassium in hypertensive patients (author's transl)]. MMW Munch Med Wochenschr. 1978 Nov 10;120(45):1505-7. German. PubMed PMID: 101820. 16: Gasser RW, Brandstetter G, Skrabal F. [Treatment of hypertension with a drug combination, consisting of bemetizide, triamterene, dihydralazine and bupranolol (author's transl)]. Wien Klin Wochenschr. 1982 Jan 8;94(1):25-8. German. PubMed PMID: 7080491. 17: Selvaag E, Thune P. Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice. Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):4-8. PubMed PMID: 9361121. 18: Schrey A, Schmidt G, Ziegler WJ. [Experiences with a combination of bemetizide and triamterene in the ambulatory treatment of hypertension. Report of a multicentric study]. Med Welt. 1978 Dec 8;29(49):1936-43. German. PubMed PMID: 732567. 19: Neumann D, Haase W. [Effect of the diuretics bemetizide and triamterene on renal excretion of potassium and sodium. Animal experiments]. Med Welt. 1977 Oct 7;28(40):1621-3. German. PubMed PMID: 927120. 20: Selvaag E. Inhibition of thiazide photohemolysis in vitro by antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Oct;12(5):211-5. PubMed PMID: 9112280.

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