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MedKoo Cat#: 585185 | Name: Epicillin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epicillin is a semisynthetic penicillin type antibiotic.

Chemical Structure

Epicillin
Epicillin
CAS#26774-90-3

Theoretical Analysis

MedKoo Cat#: 585185

Name: Epicillin

CAS#: 26774-90-3

Chemical Formula: C16H21N3O4S

Exact Mass: 351.1253

Molecular Weight: 351.42

Elemental Analysis: C, 54.69; H, 6.02; N, 11.96; O, 18.21; S, 9.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Epicillin; SQ 11,302; SQ 11302
IUPAC/Chemical Name
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3,3-dimethyl-7-oxo-, D-
InChi Key
RPBAFSBGYDKNRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H21N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-4,7,9-11,14H,5-6,17H2,1-2H3,(H,18,20)(H,22,23)
SMILES Code
O=C(C(C(C)(C)SC1C2NC(C(N)C3=CCC=CC3)=O)N1C2=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: el Zawahry M, Aziz AA, Soliman M, Shoeib S, Tadros SS. Clinical and bacteriological evaluation of a twice daily regimen of epicillin capsules for the treatment of skin infections. Br J Dermatol. 1976 Aug;95(2):177-80. PubMed PMID: 782505. 2: Philipson A, Sabath LD, Rosner B. Sequence effect on ampicillin blood levels noted in an amoxicillin, ampicillin, and epicillin triple crossover study. Antimicrob Agents Chemother. 1975 Sep;8(3):311-20. PubMed PMID: 1101821; PubMed Central PMCID: PMC429312. 3: Limson BM, Siasoco RE, Dial FP. The effect of combined sodium epicillin injection and orally administered epicillin in the treatment of acute infective illness. Med J Aust. 1972 Dec 9;2(24):1348-51. PubMed PMID: 4649994. 4: Theodoridis A, Marcollou-Kindi O, Vagana A, Sivenas C, Capetanakis J. Single oral dose of epicillin combined with probenecid in the treatment of gonorrhoea. Curr Med Res Opin. 1980;7(1):1-4. PubMed PMID: 7191790. 5: Gadebusch H, Miraglia G, Pansy F, Renz K. Epicillin: experimental chemotherapy, pharmacodynamics, and susceptibility testing. Infect Immun. 1971 Jul;4(1):50-3. PubMed PMID: 4404324; PubMed Central PMCID: PMC416263. 6: Basker MJ, Gwynn MN, White AR. Comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. Chemotherapy. 1979;25(3):170-80. PubMed PMID: 256524. 7: Bisanto J, Lembong CM, Sudibjo S, Pudjiadi SH. Epicillin and sodium epicillin in the treatment of childhood pneumonia. Paediatr Indones. 1973 May-Jun;13(5):145-50. PubMed PMID: 4786353. 8: Landa L. Epicillin in the treatment of shigellosis and salmonellosis. Curr Ther Res Clin Exp. 1971 Oct;13(10):654-9. PubMed PMID: 4338475. 9: Ryu DD, Mukherjee BB, Lee BK. Synthesis and biological activity of (2-hydroxy-1-naphthyl)-methylamino acetamido-epicillin and cephradine, and (2-hydroxy-1-naphthyl)-methylacetamido 6-APA. J Antibiot (Tokyo). 1977 Jan;30(1):66-70. PubMed PMID: 557033. 10: Brogden RN, Avery GS. New antibiotics: epicillin, minocycline and spectinomycin a summary of their antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1972;3(5):314-30. Review. PubMed PMID: 4265722. 11: Basch H, Erickson R, Gadebusch H. Epicillin: in vitro laboratory studies. Infect Immun. 1971 Jul;4(1):44-9. PubMed PMID: 4343402; PubMed Central PMCID: PMC416262. 12: Hassau A, Sippel J, Farid Z, Tadros SS, Brian M. A comparative study of epicillin and chloramphenicol in the treatment of enteric fever. J Int Med Res. 1977;5(2):91-5. PubMed PMID: 559593. 13: Hassan A, Yassin MW, Girgis NI, Sippel JE, Miner WF, Tadros SS, Abu El Ella AH. The value of epicillin and ampicillin in the treatment of meningococcal and pneumococcal meningitis. Scand J Infect Dis. 1976;8(3):181-3. PubMed PMID: 9689. 14: Caloza DL, Bernfeld GE. Clinical comparison of epicillin and ampicillin. Curr Ther Res Clin Exp. 1977 Jan;21(1):64-9. PubMed PMID: 401714. 15: Reyes-Javier PD. Epicillin in the treatment of acute superficial and soft tissue infections. Curr Ther Res Clin Exp. 1971 Sep;13(9):602-5. PubMed PMID: 4329887. 16: Boniver R. [Epicillin in the treatment of infections of the upper respiratory tract]. Brux Med. 1973 Aug;53(8):455-8. French. PubMed PMID: 4751893. 17: Scherzer W, Kraft D, Cerni C, Scheiner O, Lackner J, Spitzy KH. [Aminopenicillin rashes - a multicentric prospective study (author's transl)]. Derm Beruf Umwelt. 1980;28(6):175-81. German. PubMed PMID: 6450671. 18: Solomon S, Subramaniam S, Madanagopolan N. In vitro sensitivity of enteric bacteria to epicillin, chloramphenicol, ampicillin and furazolidone. Curr Med Res Opin. 1976;4(3):229-32. PubMed PMID: 985743. 19: Kelly DG, Cahalane SF, Adamson L. A clinical evaluation of epicillin (dexacillin) in the treatment of urinary tract infections. J Ir Med Assoc. 1972 Jul 8;65(13):342-4. PubMed PMID: 4338906. 20: Prandota J. Clinical pharmacology of antibiotics and other drugs in cystic fibrosis. Drugs. 1988 May;35(5):542-78. Review. PubMed PMID: 3293970.