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MedKoo Cat#: 573995 | Name: Dihydrolycorine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction, reduces mean arterial pressure (MAP), and reduces electrically or phenylephrine-induced hypertension. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity.

Chemical Structure

Dihydrolycorine
CAS#6271-21-2

Theoretical Analysis

MedKoo Cat#: 573995

Name: Dihydrolycorine

CAS#: 6271-21-2

Chemical Formula: C16H19NO4

Exact Mass: 289.1314

Molecular Weight: 289.33

Elemental Analysis: C, 66.42; H, 6.62; N, 4.84; O, 22.12

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Dihydrolycorine; alpha-dihydrolycorine
IUPAC/Chemical Name
(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
InChi Key
VJILFEGOWCJNIK-MGRBZGILSA-N
InChi Code
InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1
SMILES Code
O[C@@H]1[C@@H](O)C[C@]2([H])[C@@]3([H])N(CC2)CC4=CC5=C(OCO5)C=C4[C@@]31[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Dihydrolycorine, isolated from Lycoris radiate Herb, is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step.
In vitro activity:
Furthermore, this study observed the downregulation of fibrotic genes, including collagen I, TGFβ, and p-smad3, in the MI rats treated with dihydrolycorine (Figures 3(c) and 3(d)), downregulation of the apoptosis gene Bax, and upregulation of the apoptosis gene Bcl-2. Most importantly, upregulation of Runx1 after MI surgery was inhibited by dihydrolycorine treatment (Figures 3(e) and 3(f)). Reference: Oxid Med Cell Longev. 2021 Oct 23;2021:8528239. https://pubmed.ncbi.nlm.nih.gov/34725565/
In vivo activity:
This study confirmed that dihydrolycorine exhibited cardioprotective effects in vitro. First, this study found that the number of hypoxia-treated cardiomyocytes was significantly higher following the culture with dihydrolycorine at concentrations of 1.0, 5.0, 10, and 15 μM for 24 h than that observed in the control group; however, these numbers began decreasing upon at treatment with 15 μM dihydrolycorine (Figure 5(a)). Reference: Oxid Med Cell Longev. 2021 Oct 23;2021:8528239. https://pubmed.ncbi.nlm.nih.gov/34725565/
Solvent mg/mL mM comments
Solubility
DMSO 7.8 26.79
PBS (pH 7.2) 2.5 8.64
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 289.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Ni T, Huang X, Pan S, Lu Z. Dihydrolycorine Attenuates Cardiac Fibrosis and Dysfunction by Downregulating Runx1 following Myocardial Infarction. Oxid Med Cell Longev. 2021 Oct 23;2021:8528239. doi: 10.1155/2021/8528239. PMID: 34725565; PMCID: PMC8557049. 2. Chen BY, Du ZH, Zeng FD, Hu CJ, Ma GE, Hong SH. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9. Chinese. PMID: 8503287.
In vitro protocol:
1. Ni T, Huang X, Pan S, Lu Z. Dihydrolycorine Attenuates Cardiac Fibrosis and Dysfunction by Downregulating Runx1 following Myocardial Infarction. Oxid Med Cell Longev. 2021 Oct 23;2021:8528239. doi: 10.1155/2021/8528239. PMID: 34725565; PMCID: PMC8557049.
In vivo protocol:
1. Ni T, Huang X, Pan S, Lu Z. Dihydrolycorine Attenuates Cardiac Fibrosis and Dysfunction by Downregulating Runx1 following Myocardial Infarction. Oxid Med Cell Longev. 2021 Oct 23;2021:8528239. doi: 10.1155/2021/8528239. PMID: 34725565; PMCID: PMC8557049. 2. Chen BY, Du ZH, Zeng FD, Hu CJ, Ma GE, Hong SH. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9. Chinese. PMID: 8503287.
1. Chen, B.Y., Du, Z.H., Zeng, F.D., et al. Hypotensive effect of dihydrolycorine. Zhongguo Yao Li Xue Bao 14(1), 45-49 (1993). 2. Jiang, S., Yu, G., Yu, L., et al. Therapeutic effect of dihydrolycorine on focal cerebral ischemia-reperfusion injury in rats. Yunyang Yixueyuan Xuebao 28(5), 453-456 (2009).

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PF-06256142

PF-06256142