4β-Hydroxywithanolide E is a withanolide steroidal lactone that has anti-inflammatory and anticancer activities. It inhibits LPS-induced nitric oxide (NO) production and TNF-α-induced NF-κB activity. 4β-Hydroxywithanolide E inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation. It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively).3 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells.
MedKoo Cat#: 573987
Name: 4β-Hydroxywithanolide E
CAS#: 54334-04-2
Chemical Formula: C28H38O8
Exact Mass: 502.2567
Molecular Weight: 502.60
Elemental Analysis: C, 66.91; H, 7.62; O, 25.47
The following data is based on the product molecular weight 502.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
