MedKoo Cat#: 532940 | Name: COH34
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

COH34 is a novel potent and cell-active PARG inhibitor, selectively killing BRCA-mutant and PARP inhibitor-resistant cancer cells.

Chemical Structure

COH34
CAS#906439-72-3

Theoretical Analysis

MedKoo Cat#: 532940

Name: COH34

CAS#: 906439-72-3

Chemical Formula: C18H15NOS

Exact Mass: 293.0874

Molecular Weight: 293.38

Elemental Analysis: C, 73.69; H, 5.15; N, 4.77; O, 5.45; S, 10.93

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,050.00 2 Weeks
500mg USD 4,150.00 2 Weeks
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Related CAS #
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Synonym
COH34; COH-34; COH 34
IUPAC/Chemical Name
(E)-1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol
InChi Key
SFUAIBHPGDRCFL-XDHOZWIPSA-N
InChi Code
InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
SMILES Code
OC1=CC=C2C=CC=CC2=C1/C=N/SC3=CC=C(C)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Martincuks A, Zhang C, Austria T, Li YJ, Huang R, Lugo Santiago N, Kohut A, Zhao Q, Borrero RM, Shen B, Cristea M, Wang EW, Song M, Rodriguez-Rodriguez L, Yu H. Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer. J Immunother Cancer. 2024 Apr 5;12(4):e007716. doi: 10.1136/jitc-2023-007716. PMID: 38580335; PMCID: PMC11002370. 2: Chen SH, Yu X. Targeting dePARylation selectively suppresses DNA repair- defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. doi: 10.1126/sciadv.aav4340. PMID: 30989114; PMCID: PMC6457938. 3: Li P, Zhu X, Qu H, Han Z, Yao X, Wei Y, Li B, Chen H. Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells. Onco Targets Ther. 2024 Sep 6;17:741-753. doi: 10.2147/OTT.S463217. PMID: 39258222; PMCID: PMC11385694. 4: Tsuda K, Kurasaka C, Ogino Y, Sato A. Genomic and biological aspects of resistance to selective poly(ADP-ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells. Cancer Rep (Hoboken). 2023 Feb;6(2):e1709. doi: 10.1002/cnr2.1709. Epub 2022 Aug 26. PMID: 36053937; PMCID: PMC9939995.