AUNP-12 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligands, PD-L1 and PD-L2. It inhibits binding of soluble PD-1 to HEK293 cells expressing human PD-L2. AUNP-12 reverses PD-L1-induced inhibition of proliferation of PMA-stimulated, PD-1-expressing rat peripheral blood mononuclear cells and reduces tumor growth and lung metastasis in a B16/F10 mouse melanoma model.
MedKoo Cat#: 573981
Name: AUNP-12
CAS#: 1353563-85-5
Chemical Formula: C142H226N40O48
Exact Mass: 3259.6473
Molecular Weight: 3261.60
Elemental Analysis: C, 52.29; H, 6.98; N, 17.18; O, 23.55
The following data is based on the product molecular weight 3,261.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
