GLS1 Inhibitor | CAS# 1832646-52-2 | GLS1 Inhibitor

MedKoo Cat#: 573968 | Name: GLS1 Inhibitor

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GLS1 Inhibitor is an inhibitor of glutaminase 1 (GLS1). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro and reduces tumor growth. GLS1 inhibitor also increases tumor levels of glutamine and decreases tumor levels of glutamate and aspartate.

Chemical Structure

GLS1 Inhibitor

CAS#1832646-52-2

Theoretical Analysis

MedKoo Cat#: 573968

Name: GLS1 Inhibitor

CAS#: 1832646-52-2

Chemical Formula: C19H21N7O2S

Exact Mass: 411.1477

Molecular Weight: 411.48

Elemental Analysis: C, 55.46; H, 5.14; N, 23.83; O, 7.78; S, 7.79

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 550.00	2 Weeks

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Related CAS #

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Synonym

GLS1 Inhibitor; GLS1 Inhibitor-1;

IUPAC/Chemical Name

(S)-2-methoxy-2-phenyl-N-(5-(((R)-1-(pyridazin-3-yl)pyrrolidin-3-yl)amino)-1,3,4-thiadiazol-2-yl)acetamide

InChi Key

KLQLQDLJJUAEGT-ZBFHGGJFSA-N

InChi Code

InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1

SMILES Code

CO[C@H](C(NC1=NN=C(N[C@@H]2CCN(C3=CC=CN=N3)C2)S1)=O)C4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	20.0	48.60
	DMSO	20.0	48.60
	DMSO:PBS (pH 7.2) (1:3)	0.3	0.61

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 411.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Finlay, M.R.V., Anderton, M., Bailey, A., et al. Discovery of a thiadiazole-pyridazine-based allosteric glutaminase 1 inhibitor series that demonstrates oral bioavailability and activity in tumor xenograft models. J. Med. Chem. 62(14), 6540-6560 (2019).