MedKoo Cat#: 555664 | Name: DODAP
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.

Chemical Structure

DODAP
DODAP
CAS#127512-29-2

Theoretical Analysis

MedKoo Cat#: 555664

Name: DODAP

CAS#: 127512-29-2

Chemical Formula: C41H77NO4

Exact Mass: 647.5853

Molecular Weight: 648.07

Elemental Analysis: C, 75.99; H, 11.98; N, 2.16; O, 9.87

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
250mg USD 850.00 2 Weeks
1g USD 2,050.00 2 Weeks
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Related CAS #
No Data
Synonym
18:1 DAP; DODAP; DODAP (18:1);
IUPAC/Chemical Name
9Z-octadecenoic acid, 1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester
InChi Key
NYDLOCKCVISJKK-WRBBJXAJSA-N
InChi Code
InChI=1S/C41H77NO4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(43)45-38-39(37-42(3)4)46-41(44)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,39H,5-18,23-38H2,1-4H3/b21-19-,22-20-
SMILES Code
CN(CC(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)C
Appearance
Liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 648.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pippa N, Dokoumetzidis A, Demetzos C, Macheras P. On the ubiquitous presence of fractals and fractal concepts in pharmaceutical sciences: a review. Int J Pharm. 2013 Nov 18;456(2):340-52. doi: 10.1016/j.ijpharm.2013.08.087. Epub 2013 Sep 8. Review. PubMed PMID: 24025993. 2: Mokhtarieh AA, Cheong S, Kim S, Chung BH, Lee MK. Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery. Biochim Biophys Acta. 2012 Jul;1818(7):1633-41. PubMed PMID: 22465072. 3: Herringson TP, Altin JG. Convenient targeting of stealth siRNA-lipoplexes to cells with chelator lipid-anchored molecules. J Control Release. 2009 Nov 3;139(3):229-38. doi: 10.1016/j.jconrel.2009.06.034. Epub 2009 Jul 10. PubMed PMID: 19595724. 4: Auguste DT, Furman K, Wong A, Fuller J, Armes SP, Deming TJ, Langer R. Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes. J Control Release. 2008 Sep 24;130(3):266-74. doi: 10.1016/j.jconrel.2008.06.004. Epub 2008 Jun 12. PubMed PMID: 18601962; PubMed Central PMCID: PMC2608725. 5: Auguste DT, Armes SP, Brzezinska KR, Deming TJ, Kohn J, Prud'homme RK. pH triggered release of protective poly(ethylene glycol)-b-polycation copolymers from liposomes. Biomaterials. 2006 Apr;27(12):2599-608. Epub 2005 Dec 27. PubMed PMID: 16380161.