Synonym
Flutiorex; SL 72-340; SL 72340; Tiflorex
IUPAC/Chemical Name
Benzeneethanamine, N-ethyl-alpha-methyl-3-((trifluoromethyl)thio)-
InChi Key
HNONSDNCRNUTCT-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16F3NS/c1-3-16-9(2)7-10-5-4-6-11(8-10)17-12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
SMILES Code
FC(SC1=CC(CC(C)NCC)=CC=C1)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
263.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Giudicelli JF, Richer C, Berdeaux A. Preliminary assessment of flutiorex, a new anorectic drug, in man. Br J Clin Pharmacol. 1976 Feb;3(1):113-21. PubMed PMID: 788737; PubMed Central PMCID: PMC1428817.
2: Giudicelli JF, Richer C, Berdeaux A, Guessous N. Influence of sex on the clinical pharmacology of flutiorex, a new anorectic drug. Eur J Clin Pharmacol. 1976 Sep 30;10(5):325-30. PubMed PMID: 976306.
3: Kirby MJ, Carageorgiou-Markomihalakis H, Turner P. Studies with flutiorex, a new anorectic drug, on glucose uptake into human isolated skeletal muscle. Br J Clin Pharmacol. 1975 Dec;2(6):541-2. PubMed PMID: 1234019; PubMed Central PMCID: PMC1402632.
4: Mas-Chamberlin C, Gillet G, André J, Gomeni R, Dring LG, Morselli PL. The metabolism and kinetics of tiflorex in the rat. Drug Metab Dispos. 1981 Mar-Apr;9(2):150-5. PubMed PMID: 6113115.
5: Silverstone T, Fincham J, Plumley J. An evaluation of the anorectic activity in man of a sustained release formulation of tiflorex. Br J Clin Pharmacol. 1979 Apr;7(4):353-6. PubMed PMID: 444355; PubMed Central PMCID: PMC1429648.
6: Comai K, Sullivan AC. Phenethylamine inhibitors of partially purified rat and human pancreatic lipase. J Pharm Sci. 1982 Apr;71(4):418-21. PubMed PMID: 7086649.
7: Pleece SA, Kirby MJ, Redfern PH. The effect of viloxazine on drug-induced inhibition of food intake in the rat. J Pharm Pharmacol. 1980 Aug;32(8):558-60. PubMed PMID: 6106693.
8: Curtis-Prior PB, Prouteau M. Qualitative and quantitative effects of fenfluramine and tiflorex on food consumption in trained rats offered dietary choices. Int J Obes. 1983;7(6):575-81. PubMed PMID: 6654574.
