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MedKoo Cat#: 408035 | Name: SIC5-6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIC5-6 is a promising compound for the further development of bioactive separase inhibitor.

Chemical Structure

SIC5-6
SIC5-6
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 408035

Name: SIC5-6

CAS#: Unknown

Chemical Formula: C27H24IN3O2S

Exact Mass: 581.0634

Molecular Weight: 581.47

Elemental Analysis: C, 55.77; H, 4.16; I, 21.82; N, 7.23; O, 5.50; S, 5.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SIC5-6; SIC-5-6; SIC 5-6; SIC56; SIC-56; SIC 56;
IUPAC/Chemical Name
3,3'-(1-((4-iodophenyl)sulfonyl)piperidine-4,4-diyl)bis(1H-indole)
InChi Key
JRVKJWXBSOQUOI-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H24IN3O2S/c28-19-9-11-20(12-10-19)34(32,33)31-15-13-27(14-16-31,23-17-29-25-7-3-1-5-21(23)25)24-18-30-26-8-4-2-6-22(24)26/h1-12,17-18,29-30H,13-16H2
SMILES Code
IC1=CC=C(S(N2CCC(C3=CNC4=C3C=CC=C4)(C5=CNC6=C5C=CC=C6)CC2)(=O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Separase, a cysteine protease of the CD clan, triggers chromosome segregation during mitosis by cleaving the cohesin ring entrapping the two sister chromatids. Deregulated separase activity is associated with aneuploidy, a hallmark of most human cancers. In fact, separase is highly overexpressed in many solid cancers, making it an attractive chemotherapeutic target.

Preparing Stock Solutions

The following data is based on the product molecular weight 581.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Identification of Bioactive Small Molecule Inhibitors of Separase Lars HenschkeMatthias FreseSusanne HellmuthAndreas MarxOlaf StemmannThomas U. Mayer* ACS Chemical Biology, Articles ASAP (As Soon As Publishable)Subscribed Access Publication Date (Web):September 25, 2019