MedKoo Cat#: 555648 | Name: PFI-653
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PFI-653, also known as Vanin-1-IN-1, is an inhibitor of vanin-1 (VNN1) enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation.

Chemical Structure

PFI-653
PFI-653
CAS#2173134-00-2

Theoretical Analysis

MedKoo Cat#: 555648

Name: PFI-653

CAS#: 2173134-00-2

Chemical Formula: C18H22N6O2

Exact Mass: 354.1804

Molecular Weight: 354.41

Elemental Analysis: C, 61.00; H, 6.26; N, 23.71; O, 9.03

Price and Availability

Size Price Availability Quantity
200mg USD 1,050.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,450.00 2 Weeks
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Related CAS #
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Synonym
PFI-653; PFI 653; PFI653; Vanin-1-IN-1; Vanin-1IN-1; Vanin-1 IN-1;
IUPAC/Chemical Name
(2-((pyrazin-2-ylmethyl)amino)pyrimidin-5-yl)(8-oxa-2-azaspiro[4.5]decan-2-yl)methanone
InChi Key
VGRLXWFIXGZRMS-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22N6O2/c25-16(24-6-1-18(13-24)2-7-26-8-3-18)14-9-21-17(22-10-14)23-12-15-11-19-4-5-20-15/h4-5,9-11H,1-3,6-8,12-13H2,(H,21,22,23)
SMILES Code
O=C(N1CC2(CCOCC2)CC1)C3=CN=C(NCC4=NC=CN=C4)N=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 354.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Tredup, C., Ndreshkjana, B., Schneider, N. S., Tjaden, A., Kemas, A. M., Youhanna, S., ... & Müller, S. (2023). Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. ACS Chemical Biology, 18(4), 822-836.