Synonym
SK 946; SK946; SK-946
IUPAC/Chemical Name
N-(2-(1-azabicyclo(3.3.0)octan-5-yl)ethyl)-2-nitroaniline
InChi Key
AHHCXLBOXUCBRJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21N3O2/c19-18(20)14-6-2-1-5-13(14)16-10-9-15-7-3-11-17(15)12-4-8-15/h1-2,5-6,16H,3-4,7-12H2
SMILES Code
O=[N+](C1=CC=CC=C1NCCC23CCCN2CCC3)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Suzuki T, Inagaki H, Hamajima H, Uesaka H, Hori K, Ikami T. Synthesis and biological activity of the metabolites of N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline fumarate (SK-946). Chem Pharm Bull (Tokyo). 1999 Jun;47(6):880-3. PubMed PMID: 10399840.
2: Suzuki T, Hirooka K, Kanda K, Hirooka H, Furusawa K. Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models. Biol Pharm Bull. 1998 Jul;21(7):698-703. PubMed PMID: 9703252.
3: Suzuki T, Oka M, Maeda K, Furusawa K, Mitani T, Kataoka T. N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline, a potent muscarinic agonist. Chem Pharm Bull (Tokyo). 1997 Jul;45(7):1218-20. PubMed PMID: 9246754.
4: Suzuki T, Hirooka K, Kanda K, Uesaka H, Hirooka H, Furusawa K. Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator. Biol Pharm Bull. 1998 Jul;21(7):704-9. PubMed PMID: 9703253.
5: Suzuki T, Oka M, Maeda K, Furusawa K, Uesaka H, Kataoka T. Synthesis and muscarinic activity of novel aniline derivatives with a 1-azabicyclo[3.3.0]octane moiety. Chem Pharm Bull (Tokyo). 1999 Jan;47(1):28-36. PubMed PMID: 9987823.
