Synonym
Propylene glycol dicaprate; 1,2-Propanediol didecanoate; Propylene didecanoate; 1,2-Propylene glycol didecanoate.
IUPAC/Chemical Name
(S)-propane-1,2-diyl bis(decanoate)
InChi Key
NFIHXTUNNGIYRF-NRFANRHFSA-N
InChi Code
InChI=1S/C23H44O4/c1-4-6-8-10-12-14-16-18-22(24)26-20-21(3)27-23(25)19-17-15-13-11-9-7-5-2/h21H,4-20H2,1-3H3/t21-/m0/s1
SMILES Code
C(CCCCCCCCC)(=O)OC[C@@H](OC(=O)CCCCCCCCC)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
384.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jaworska M, Sikora E, Zielina M, Ogonowski J. Studies on the formation of O/W nano-emulsions, by low-energy emulsification method, suitable for cosmeceutical applications. Acta Biochim Pol. 2013;60(4):779-82. PubMed PMID: 24432331.
2: Dueva-Koganov OV, Mandalia Y, Brito J, Rocafort C, Orofino S, Vazquez G. In vitro/in vivo and analytical evaluation of sunless tanning formulations containing different rheology modifiers. J Cosmet Sci. 2010 Mar-Apr;61(2):73-83. PubMed PMID: 20447361.
3: Goddeeris C, Goderis B, Van den Mooter G. Lyotropic, liquid crystalline nanostructures of aqueous dilutions of SMEDDS revealed by small-angle X-ray scattering: impact on solubility and drug release. Eur J Pharm Sci. 2010 May 12;40(2):110-7. doi: 10.1016/j.ejps.2010.03.005. Epub 2010 Mar 16. PubMed PMID: 20298780.
4: Buyukozturk F, Benneyan JC, Carrier RL. Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics. J Control Release. 2010 Feb 25;142(1):22-30. doi: 10.1016/j.jconrel.2009.10.005. Epub 2009 Oct 20. PubMed PMID: 19850092.
5: Chow KT, Chan LW, Heng PW. Characterization of spreadability of nonaqueous ethylcellulose gel matrices using dynamic contact angle. J Pharm Sci. 2008 Aug;97(8):3467-82. PubMed PMID: 17969118.
6: Chan LW, Chow KT, Heng PW. Investigation of wetting behavior of nonaqueous ethylcellulose gel matrices using dynamic contact angle. Pharm Res. 2006 Feb;23(2):408-21. Epub 2006 Jan 12. PubMed PMID: 16397742.
7: Heng PW, Chan LW, Chow KT. Development of novel nonaqueous ethylcellulose gel matrices: rheological and mechanical characterization. Pharm Res. 2005 Apr;22(4):676-84. Epub 2005 Apr 7. PubMed PMID: 15846476.
8: Subramanian N, Ghosal SK, Moulik SP. Topical delivery of celecoxib using microemulsion. Acta Pol Pharm. 2004 Sep-Oct;61(5):335-41. PubMed PMID: 15747689.
