Azosemide | CAS#27589-33-9 | diuretic

MedKoo Cat#: 585154 | Name: Azosemide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azosemide is used in the treatment of oedematous states and hypertension.

Chemical Structure

Azosemide

CAS#27589-33-9

Theoretical Analysis

MedKoo Cat#: 585154

Name: Azosemide

CAS#: 27589-33-9

Chemical Formula: C12H11ClN6O2S2

Exact Mass: 370.0073

Molecular Weight: 370.83

Elemental Analysis: C, 38.87; H, 2.99; Cl, 9.56; N, 22.66; O, 8.63; S, 17.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Azosemide; PLE 1053; SK-110

IUPAC/Chemical Name

Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenyl-

InChi Key

HMEDEBAJARCKCT-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

SMILES Code

NS(=O)(C1=CC(C2=NN=NN2)=C(NCC3=CC=CS3)C=C1Cl)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Effects of Long-Acting Loop Diuretics in Heart Failure With Reduced Ejection Fraction Patients With Cardiac Resynchronization Therapy. Int Heart J. 2017 Apr 6;58(2):211-219. doi: 10.1536/ihj.16-290. Epub 2017 Mar 17. PubMed PMID: 28321027. 11: Hori Y, Katou A, Tsubaki M, Kanai K, Nakao R, Hoshi F, Itoh N, Higuchi S. Assessment of diuretic effects and changes in plasma aldosterone concentration following oral administration of a single dose of furosemide or azosemide in healthy dogs. Am J Vet Res. 2008 Dec;69(12):1664-9. doi: 10.2460/ajvr.69.12.1664. PubMed PMID: 19046016. 12: Kitada S, Kikuchi S, Tsujino T, Masuyama T, Ohte N; J-MELODIC study investigators. The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub-analysis of the J-MELODIC study. ESC Heart Fail. 2018 Feb;5(1):36-45. doi: 10.1002/ehf2.12206. Epub 2017 Sep 21. 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Circadian changes in the pharmacokinetics and pharmacodynamics of azosemide in rats. J Pharm Pharmacol. 1998 Jul;50(7):767-74. PubMed PMID: 9720626. 17: Suzuki Y, Ito M, Komura T. [Pharmacological studies on the diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (3). Effect of azosemide following pretreatment with SA-446, an angiotensin I converting enzyme inhibitor, or propranolol, a beta-adrenergic blocker, in HgCl2-induced acute renal failure in rats]. Nihon Yakurigaku Zasshi. 1982 Nov;80(5):395-404. Japanese. PubMed PMID: 6187650. 18: Choi KY, Kim YC, Lee MG. Mechanism of enhanced bioavailability and diuretic effect of azosemide by ascorbic acid in rats. Life Sci. 2006 Feb 2;78(10):1057-62. Epub 2005 Sep 8. PubMed PMID: 16153662. 19: Lee SH, Lee MG. Pharmacokinetics and pharmacodynamics of azosemide after intravenous and oral administration to rats: absorption from various GI segments. 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