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MedKoo Cat#: 585153 | Name: Pentifylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pentifylline is a useful biochemical for proteomics research.

Chemical Structure

Pentifylline
Pentifylline
CAS#1028-33-7

Theoretical Analysis

MedKoo Cat#: 585153

Name: Pentifylline

CAS#: 1028-33-7

Chemical Formula: C13H20N4O2

Exact Mass: 264.1586

Molecular Weight: 264.33

Elemental Analysis: C, 59.07; H, 7.63; N, 21.20; O, 12.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pentifylline; SK 7; Cosadon; Cosaldon; Pentifyllin
IUPAC/Chemical Name
1H-Purine-2,6-dione, 3,7-dihydro-1-hexyl-3,7-dimethyl-
InChi Key
MRWQRJMESRRJJB-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N4O2/c1-4-5-6-7-8-17-12(18)10-11(14-9-15(10)2)16(3)13(17)19/h9H,4-8H2,1-3H3
SMILES Code
O=C(N1CCCCCC)N(C)C2=C(N(C)C=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 264.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bath PM, Bath FJ, Asplund K. Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. Cochrane Database Syst Rev. 2000;(2):CD000162. Review. Update in: Cochrane Database Syst Rev. 2004;(3):CD000162. PubMed PMID: 10796310. 2: Bath PM, Bath-Hextall FJ. Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. Cochrane Database Syst Rev. 2004;(3):CD000162. Review. PubMed PMID: 15266424. 3: Dagenais M, Pomier-Layrargues G, Rocheleau B, Giroux L, Huet PM. Systemic and splanchnic haemodynamic effects of pentifylline in rats with portal hypertension. Clin Sci (Lond). 1992 Jul;83(1):41-5. PubMed PMID: 1325320. 4: Strutz F, Heeg M, Kochsiek T, Siemers G, Zeisberg M, Müller GA. Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Nephrol Dial Transplant. 2000 Oct;15(10):1535-46. PubMed PMID: 11007820. 5: Porsche E, Stefanovich V. [The influence of pentifylline and theophylline on reaction kinetics on rat brain ATPase stimulatable by catecholamines (author's transl)]. Arzneimittelforschung. 1979;29(8):1089-92. German. PubMed PMID: 227424. 6: Jordaan B, Oliver DW, Dormehl IC, Hugo N. Cerebral blood flow effects of piracetam, pentifylline, and nicotinic acid in the baboon model compared with the known effect of acetazolamide. Arzneimittelforschung. 1996 Sep;46(9):844-7. PubMed PMID: 8876930. 7: Gessner B, Klasser M. [Influence of a Pentifylline-Nicotinic Acid Combination on Vigilance and Mental Performance (author's transl)]. Arzneimittelforschung. 1982;32(5):579-83. German. PubMed PMID: 7201838. 8: Stefanovich V, John JP. Influence of pentifylline on brain metabolism of normal and anoxic rats. Arzneimittelforschung. 1978;28(11):2097-9. PubMed PMID: 582912. 9: Saika S, Yamanaka O, Okada Y, Tanaka S, Ohnishi Y, Ooshima A. Pentoxifylline and pentifylline inhibit proliferation of human Tenon's capsule fibroblasts and production of type-I collagen and laminin in vitro. Ophthalmic Res. 1996;28(3):165-70. PubMed PMID: 8829173. 10: Duncan MR, Hasan A, Berman B. Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation. J Invest Dermatol. 1995 Feb;104(2):282-6. PubMed PMID: 7530274. 11: Stefanovich V. Inhibition of platelet cyclic 3',5'-adenosine-monophosphate phosphodiesterases by pentifylline. Arzneimittelforschung. 1975 May;25(5):740-1. PubMed PMID: 170944. 12: Dormehl IC, Jordaan B, Oliver DW, Croft S. SPECT monitoring of improved cerebral blood flow during long-term treatment of elderly patients with nootropic drugs. Clin Nucl Med. 1999 Jan;24(1):29-34. PubMed PMID: 9890490. 13: Stefanovich V, von Pölnitz M, Reiser M. Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline. Arzneimittelforschung. 1974 Nov;24(11):1747-51. PubMed PMID: 4374953. 14: Meiring L. Nicotinic acid and pentifylline for hyperlipoproteinaemia. S Afr Med J. 1980 Mar 8;57(10):345. PubMed PMID: 7403980. 15: Oliver DW, Dormehl IC, Louw WK. Non-human primate SPECT model for determining cerebral perfusion effects of cerebrovasoactive drugs acting via multiple modes of pharmacological action. J Neurol Sci. 2005 Mar 15;229-230:255-9. Epub 2005 Jan 11. PubMed PMID: 15760648. 16: Wei D, Zhang L, Williams DL, Browder IW. Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism. Wound Repair Regen. 2002 May-Jun;10(3):161-8. PubMed PMID: 12100377. 17: UEKI S, ODA M, IWAKI J. [Pharmacology of 1-hexyl-3, 7-dimethylxanthine (SK-7)]. Fukuoka Igaku Zasshi. 1962 Mar;53:187-96. Japanese. PubMed PMID: 13923515. 18: Bhoir IC, Raman B, Sundaresan M, Bhagwat AM. Separation and estimation of seven vasodilators using packed column supercritical fluid chromatography. J Pharm Biomed Anal. 1998 Jul;17(3):539-46. PubMed PMID: 9656167. 19: CUGURRA F, ECHINARD-GARIN P. [Some aspects of the pharmacological activity of a new theophylline: 1-hexyl-3, 7-dimethylxanthine (SK-7)]. Arch Int Pharmacodyn Ther. 1960 Jan 1;123:481-9. Italian. PubMed PMID: 13813225. 20: Collier HO, Cuthbert NJ, Francis DL. Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines. Fed Proc. 1981 Apr;40(5):1513-8. PubMed PMID: 6163662.

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