Betiatide | CAS#103725-47-9 | diagnostic

MedKoo Cat#: 585139 | Name: Betiatide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Betiatide is a technetium diagnostic aid used in renal function determination.

Chemical Structure

Betiatide

CAS#103725-47-9

Theoretical Analysis

MedKoo Cat#: 585139

Name: Betiatide

CAS#: 103725-47-9

Chemical Formula: C15H17N3O6S

Exact Mass: 367.0838

Molecular Weight: 367.38

Elemental Analysis: C, 49.04; H, 4.66; N, 11.44; O, 26.13; S, 8.73

Price and Availability

Size	Price	Availability
10mg	USD 550.00	2 Weeks
50mg	USD 950.00	2 Weeks
500mg	USD 2,950.00	2 Weeks
1g	USD 4,650.00	2 Weeks

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Related CAS #

No Data

Synonym

Betiatide; MP 600; MP-600; MP600; Technescan MAG3

IUPAC/Chemical Name

Glycine, N-(N-(N-((benzoylthio)acetyl)glycyl)glycyl)

InChi Key

VDPYMEBVIDZKMD-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H17N3O6S/c19-11(16-6-12(20)18-8-14(22)23)7-17-13(21)9-25-15(24)10-4-2-1-3-5-10/h1-5H,6-9H2,(H,16,19)(H,17,21)(H,18,20)(H,22,23)

SMILES Code

O=C(O)CNC(CNC(CNC(CSC(C1=CC=CC=C1)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 367.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mannelli L, Monti S, Bastawrous S, Lomabardo I, Behnia F. Vesicocolic fistula detected by (99m)Tc-MAG3 renogram. Clin Nucl Med. 2015 Jan;40(1):73-5. doi: 10.1097/RLU.0000000000000571. PubMed PMID: 25140566. 2: Lee SF, Lichtenstein M, Hughes P, Sivaratnam D. Utility of MAG3 scintigraphy with the use of a 2 min uptake parameter in the assessment of postsurgical renal transplant complications. Nucl Med Commun. 2018 Oct;39(10):921-927. doi: 10.1097/MNM.0000000000000885. PubMed PMID: 30074536. 3: Nishi K, Kobayashi M, Nishii R, Shikano N, Takamura N, Kuga N, Yamasaki K, Nagamachi S, Tamura S, Otagiri M, Kawai K. Pharmacokinetic alteration of (99m)Tc-MAG3 using serum protein binding displacement method. Nucl Med Biol. 2013 Apr;40(3):366-70. doi: 10.1016/j.nucmedbio.2012.12.002. Epub 2013 Jan 9. PubMed PMID: 23312701. 4: Arteaga MV, Caballero VM, Rengifo KM. Dosimetry of (99m)Tc (DTPA, DMSA and MAG3) used in renal function studies of newborns and children. Appl Radiat Isot. 2018 Aug;138:25-28. doi: 10.1016/j.apradiso.2017.07.054. Epub 2017 Jul 28. PubMed PMID: 28781122. 5: Taylor AT, Folks RD, Rahman AKMF, Polsani A, Dubovsky EV, Halkar R, Manatunga A. (99m)Tc-MAG(3): Image Wisely. Radiology. 2017 Jul;284(1):200-209. doi: 10.1148/radiol.2017152311. Epub 2017 Feb 17. PubMed PMID: 28212051; PubMed Central PMCID: PMC5495132. 6: Rehling M, Frøkiaer J, Poulsen EU, Marqversen J, Nielsen BV, Bacher T. 99mTc-MAG3 kinetics in the normal pig. A comparison to 131I-OIH and 125I-iothalamate after single injection and during continuous infusion. Clin Physiol. 1995 Jan;15(1):57-71. PubMed PMID: 7712693. 7: Jain V, Arora S, Passah A, Mani K, Yadav DK, Goel P, Gupta DK. Comparison of the renal dynamic scan performed with 99mTc-L,L-EC and 99mTc-MAG3 in children with pelviureteric junction obstruction. Nucl Med Commun. 2018 Nov;39(11):1053-1058. doi: 10.1097/MNM.0000000000000902. PubMed PMID: 30169343. 8: Assmus MA, Kiddoo DA, Hung RW, Metcalfe PD. Initially Asymmetrical Function on MAG3 Renography Increases Incidence of Adverse Outcomes. J Urol. 2016 Apr;195(4 Pt 2):1196-202. doi: 10.1016/j.juro.2015.11.011. Epub 2016 Feb 28. PubMed PMID: 26926535. 9: Esteves FP, Taylor A, Manatunga A, Folks RD, Krishnan M, Garcia EV. 99mTc-MAG3 renography: normal values for MAG3 clearance and curve parameters, excretory parameters, and residual urine volume. AJR Am J Roentgenol. 2006 Dec;187(6):W610-7. PubMed PMID: 17114514. 10: Mustafa S, Elgazzar AH. Effect of the NSAID diclofenac on 99mTc-MAG3 and 99mTc-DTPA renography. J Nucl Med. 2013 May;54(5):801-6. doi: 10.2967/jnumed.112.109595. Epub 2013 Mar 25. PubMed PMID: 23528384. 11: Santos AI, Violante L, Carmona S, Prata A, Rodrigues Victor M, Santos JG, Araújo Sequeira J, Alves M, Papoila AL, Piepsz A. Interobserver agreement on cortical tracer transit in 99mTc-MAG3 renography applied to congenital hydronephrosis. Nucl Med Commun. 2017 Feb;38(2):124-128. doi: 10.1097/MNM.0000000000000620. PubMed PMID: 27851658. 12: Da Rocha Gomes S, Miguel J, Azéma L, Eimer S, Ries C, Dausse E, Loiseau H, Allard M, Toulmé JJ. (99m)Tc-MAG3-aptamer for imaging human tumors associated with high level of matrix metalloprotease-9. Bioconjug Chem. 2012 Nov 21;23(11):2192-200. doi: 10.1021/bc300146c. Epub 2012 Nov 1. PubMed PMID: 23043415. 13: Shattuck LA, Eshima D, Taylor AT Jr, Anderson TL, Graham DL, Latino FA, Payne SE. Evaluation of the hepatobiliary excretion of technetium-99m-MAG3 and reconstitution factors affecting radiochemical purity. J Nucl Med. 1994 Feb;35(2):349-55. PubMed PMID: 8295009. 14: van Gog FB, Visser GW, Gowrising RW, Snow GB, van Dongen GA. Synthesis and evaluation of 99mTc/99Tc-MAG3-biotin conjugates for antibody pretargeting strategies. Nucl Med Biol. 1998 Oct;25(7):611-9. PubMed PMID: 9804042. 15: van Gog FB, Visser GW, Klok R, van der Schors R, Snow GB, van Dongen GA. Monoclonal antibodies labeled with rhenium-186 using the MAG3 chelate: relationship between the number of chelated groups and biodistribution characteristics. J Nucl Med. 1996 Feb;37(2):352-62. PubMed PMID: 8667076. 16: Pogatchnik B, Monti S, Lewis DH, Heinrich DA, Mannelli L. Intraperitoneal urine leak after prostatectomy confirmed by 99mTc-MAG3 renogram. Clin Nucl Med. 2014 Aug;39(8):744-6. doi: 10.1097/RLU.0000000000000442. PubMed PMID: 24873796. 17: Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y. Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development. Nucl Med Biol. 2013 Jul;40(5):643-50. doi: 10.1016/j.nucmedbio.2013.03.006. Epub 2013 Apr 22. PubMed PMID: 23618840. 18: Guhlke S, Schaffland A, Zamora PO, Sartor J, Diekmann D, Bender H, Knapp FF, Biersack HJ. 188Re- and 99mTc-MAG3 as prosthetic groups for labeling amines and peptides: approaches with pre- and postconjugate labeling. Nucl Med Biol. 1998 Oct;25(7):621-31. PubMed PMID: 9804043. 19: Visser GW, Gerretsen M, Herscheid JD, Snow GB, van Dongen G. Labeling of monoclonal antibodies with rhenium-186 using the MAG3 chelate for radioimmunotherapy of cancer: a technical protocol. J Nucl Med. 1993 Nov;34(11):1953-63. PubMed PMID: 8229241. 20: Afshan A, Sohaib M, Jehangir M. Formulation of lyophilized single vial kit of N-N-Ethylene-L-Dicysteine (EC) for labeling with (99m)Tc. II: Radiochemical and clinical evaluation as a renal tubular agent in comparison with (99m)Tc-MAG3. Pak J Pharm Sci. 2017 Jul;30(4):1289-1295. PubMed PMID: 29039327.