IUPAC/Chemical Name
Carbamothioic acid, (2-chloroethyl)-, S-1H-purin-6-yl ester
InChi Key
OQBORDVFGPUGDV-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8ClN5OS/c9-1-2-10-8(15)16-7-5-6(12-3-11-5)13-4-14-7/h3-4H,1-2H2,(H,10,15)(H,11,12,13,14)
SMILES Code
O=C(SC1=C2N=CN=C2N=CN1)NCCCl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
257.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Miko M, Krepelka J, Melka M. Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80. PubMed PMID: 3229320.
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4: Francová V, Smolík S, Ráz K, Brejcha A, Franc Z, Vortel V, Cerný A, Krepelka J, Mĕlka M. [Substances with antineoplastic effects. XCVI. Separation of (35S) cloturin in tissue, blood and the digestive system and its excretion in rats]. Cesk Farm. 1988 Jul;37(6):246-50. Czech. PubMed PMID: 3180266.
5: Marhan J. Mutagenicity of cytostatic drugs in a bacterial system. I. Ames test. Folia Microbiol (Praha). 1995;40(5):457-61. PubMed PMID: 8763144.
6: Mĕlka M, Krepelka J, Miko M, Pokorná S, Kejhová I, Reichlová R, Beitová M, Grimová J, Kargerová A, Sedivá J. Substances with antineoplastic activity. XCVI. Some pharmacological properties and therapeutic synergism of 6-purinyl-N-(2-chloroethyl)thiocarbamate with cytosine arabinoside. Neoplasma. 1989;36(4):419-25. PubMed PMID: 2671756.
7: Marhan J. Mutagenicity of cytostatic drugs in a bacterial system. II. DNA-repair test. Folia Microbiol (Praha). 1995;40(5):462-66. PubMed PMID: 8763145.
8: Miko M, Krepelka J, Melka M. Primary screening of cytotoxic activity of 6-purinyl-N-(2-chlordethyl) thiocarbamate. J Chemother. 1989 Jul;1(4 Suppl):1142-4. PubMed PMID: 16312809.
