Zelquistinel, also known as AGN-241751 and GATE-251, is an orally active small-molecule NMDA receptor modulator which is under development for the treatment of major depressive disorder (MDD). Zelquistinel acts through a unique binding site on the NMDA receptor, independent of the glycine site, to modulate receptor activity and enhance NMDAR-mediated synaptic plasticity. Its mechanism of action is similar to that of rapastinel. However, unlike rapastinel, zelquistinel is orally bioavailable, exhibits increased potency, and has improved drug properties.
MedKoo Cat#: 581952
Name: Zelquistinel
CAS#: 2151842-64-5
Chemical Formula: C15H25N3O5
Exact Mass: 327.1800
Molecular Weight: 327.38
Elemental Analysis: C, 55.03; H, 7.70; N, 12.84; O, 24.43
The following data is based on the product molecular weight 327.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
