SWE101 | CAS#2376322-12 | sEH-P inhibitor

MedKoo Cat#: 555622 | Name: SWE101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SWE101 is a potent sEH-P inhibitor (IC50 = 58nM). SWE101 is the first in Vivo Active Inhibitor of the Soluble Epoxide Hydrolase Phosphatase Domain. SWE101 has an excellent pharmacokinetic and pharmacodynamic profile in rats and enables the investigation of the physiological and pathophysiological role of sEH-P in vivo.

Chemical Structure

SWE101

CAS#2376322-12

Theoretical Analysis

MedKoo Cat#: 555622

Name: SWE101

CAS#: 2376322-12

Chemical Formula: C19H15Cl2NO3

Exact Mass: 375.0429

Molecular Weight: 376.23

Elemental Analysis: C, 60.66; H, 4.02; Cl, 18.84; N, 3.72; O, 12.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SWE101; SWE-101; SWE 101;

IUPAC/Chemical Name

4-(4-(3,4-Dichlorophenyl)-5-phenyloxazol-2-yl)butanoic acid

InChi Key

UIADWSXPNFQQCZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H15Cl2NO3/c20-14-10-9-13(11-15(14)21)18-19(12-5-2-1-3-6-12)25-16(22-18)7-4-8-17(23)24/h1-3,5-6,9-11H,4,7-8H2,(H,23,24)

SMILES Code

O=C(O)CCCC1=NC(C2=CC=C(Cl)C(Cl)=C2)=C(C3=CC=CC=C3)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-terminal hydrolase domain is well-investigated, little is known about its phosphatase activity, located in the N-terminal phosphatase domain of sEH (sEH-P). The sEH inhibitors hold promising therapeutical potential for various diseases, including diabetes, fibrosis, chronic pain, and cardiovascular and neurodegenerative diseases

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 376.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. J Med Chem. 2019 Sep 26;62(18):8443-8460. doi: 10.1021/acs.jmedchem.9b00445. Epub 2019 Sep 17. PubMed PMID: 31436984.