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MedKoo Cat#: 573927 | Name: Adoprazine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adoprazine hydrochloride is a dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug.

Chemical Structure

Adoprazine hydrochloride
CAS#222551-05-5

Theoretical Analysis

MedKoo Cat#: 573927

Name: Adoprazine hydrochloride

CAS#: 222551-05-5

Chemical Formula: C24H25ClFN3O2

Exact Mass: 441.1619

Molecular Weight: 441.93

Elemental Analysis: C, 65.23; H, 5.70; Cl, 8.02; F, 4.30; N, 9.51; O, 7.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Adoprazine HCl, Adoprazine hydrochloride, Adoprazine monohydrochloride, SLV-313 HCl, SLV313 HCl, SLV 313 HCl
IUPAC/Chemical Name
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)-, hydrochloride (1:1)
InChi Key
PAPGPUNOWOEIPA-UHFFFAOYSA-N
InChi Code
1S/C24H24FN3O2.ClH/c25-21-6-4-19(5-7-21)20-14-18(15-26-16-20)17-27-8-10-28(11-9-27)22-2-1-3-23-24(22)30-13-12-29-23;/h1-7,14-16H,8-13,17H2;1H
SMILES Code
c1cc(c2c(c1)OCCO2)N3CCN(CC3)Cc4cc(cnc4)c5ccc(cc5)F.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 441.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Auclair AL, Kleven MS, Barret-Grévoz C, Barreto M, Newman-Tancredi A, Depoortère R. Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. Behav Brain Res. 2009 Nov 5;203(2):288-95. doi: 10.1016/j.bbr.2009.05.015. Epub 2009 May 21. PubMed PMID: 19464324. 2: Depoortère R, Barret-Grévoz C, Bardin L, Newman-Tancredi A. Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds. Eur J Pharmacol. 2008 Nov 12;597(1-3):34-8. doi: 10.1016/j.ejphar.2008.08.011. Epub 2008 Aug 24. PubMed PMID: 18773888. 3: Assié MB, Carilla-Durand E, Bardin L, Maraval M, Aliaga M, Malfètes N, Barbara M, Newman-Tancredi A. The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063. Eur J Pharmacol. 2008 Sep 11;592(1-3):160-6. doi: 10.1016/j.ejphar.2008.06.105. Epub 2008 Jul 4. PubMed PMID: 18640111.