Synonym
DASA-58; DASA 58; DASA58; ML-203; ML 203; ML203; NCGC00185916; NCGC-00185916; NCGC 00185916;
IUPAC/Chemical Name
3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-benzenamine
InChi Key
GMHIOMMKSMSRLY-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2
SMILES Code
O=S(N1CCN(S(C2=CC=C(OCCO3)C3=C2)(=O)=O)CCC1)(C4=CC(N)=CC=C4)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
453.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi
B, Raugei G, Wong N, Tang D, Chiarugi P. Targeting stromal-induced pyruvate
kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic
spread. Oncotarget. 2015 Sep 15;6(27):24061-74. PubMed PMID: 26183399; PubMed
Central PMCID: PMC4695170.
2: Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE,
van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen
WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. Pyruvate
kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical
determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015
Jan 6;21(1):65-80. doi: 10.1016/j.cmet.2014.12.005. Erratum in: Cell Metab. 2015
Feb 3;21(2):347. Jiang, Jain-Kang [corrected to Jiang, Jian-Kang]; Vanden Heiden,
Matthew [corrected to Vander Heiden, Matthew]. Cell Metab. 2015 Feb 3;21(2):347.
PubMed PMID: 25565206; PubMed Central PMCID: PMC5198835.
