K252d | CAS#105114-22-5 | inhibitor

MedKoo Cat#: 585108 | Name: K252d

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

K252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain, as well as, calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart.

Chemical Structure

K252d

CAS#105114-22-5

Theoretical Analysis

MedKoo Cat#: 585108

Name: K252d

CAS#: 105114-22-5

Chemical Formula: C26H23N3O5

Exact Mass: 457.1638

Molecular Weight: 457.49

Elemental Analysis: C, 68.26; H, 5.07; N, 9.19; O, 17.49

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 585.00	2 Weeks

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Related CAS #

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Synonym

K252d

IUPAC/Chemical Name

13-(6-deoxy-α-L-mannopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

InChi Key

FYQXRIMLEOPQQP-DDWDLLSFSA-N

InChi Code

InChI=1S/C26H23N3O5/c1-11-22(30)23(31)24(32)26(34-11)29-16-9-5-3-7-13(16)18-19-14(10-27-25(19)33)17-12-6-2-4-8-15(12)28-20(17)21(18)29/h2-9,11,22-24,26,28,30-32H,10H2,1H3,(H,27,33)/t11-,22-,23+,24+,26+/m0/s1

SMILES Code

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 457.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Nakanishi, S., Matsuda, Y., Iwahashi, K., et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39(8), 1066-1071 (1986).