MedKoo Cat#: 555611 | Name: DV2-103

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DV2-103 is a kinase inactive analogue of a potent Abl1/Src kinase inhibitor, PD173955. DV2-103 showed to potently reduce production of secreted β- amyloid (Aβ) peptide in cells.

Chemical Structure

DV2-103
DV2-103
CAS#730979-43

Theoretical Analysis

MedKoo Cat#: 555611

Name: DV2-103

CAS#: 730979-43

Chemical Formula: C18H17Cl2N5O

Exact Mass: 389.0810

Molecular Weight: 390.27

Elemental Analysis: C, 55.40; H, 4.39; Cl, 18.17; N, 17.95; O, 4.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
DV2-103; DV2103; DV2 103; DV 2103; DV-2103;
IUPAC/Chemical Name
6-(2,6-dichlorophenyl)-8-methyl-2-(piperazin-1-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
InChi Key
NIGHBORAEFSARV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17Cl2N5O/c1-24-16-11(10-22-18(23-16)25-7-5-21-6-8-25)9-12(17(24)26)15-13(19)3-2-4-14(15)20/h2-4,9-10,21H,5-8H2,1H3
SMILES Code
O=C1N(C)C2=NC(N3CCNCC3)=NC=C2C=C1C4=C(Cl)C=CC=C4Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Netzer WJ, Bettayeb K, Sinha SC, Flajolet M, Greengard P, Bustos V. Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1389-1394. doi: 10.1073/pnas.1620963114. Epub 2017 Jan 23. PubMed PMID: 28115709; PubMed Central PMCID: PMC5307477.