Synonym
RJW100; RJW-100; RJW 100;
IUPAC/Chemical Name
(1R,3aR,6aR)-5-Hexyl-4-phenyl-3a-(1-phenylvinyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol
InChi Key
ZFXMYHPLTQTTFW-REUBFRLUSA-N
InChi Code
InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
SMILES Code
O[C@@H]1CC[C@@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@@]12[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
386.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT,
Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver
Receptor Homolog 1, Bound to Synthetic Agonists. J Biol Chem. 2016 Dec
2;291(49):25281-25291. Epub 2016 Sep 30. PubMed PMID: 27694446; PubMed Central
PMCID: PMC5207232.
2: de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP,
Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New,
Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).
PLoS One. 2016 Jul 28;11(7):e0159316. doi: 10.1371/journal.pone.0159316.
eCollection 2016. PubMed PMID: 27467220; PubMed Central PMCID: PMC4965143.
3: Bellevue OC, Johnson BM, Feczko AF, Nadig DE, White DM. Theatrical fire
pursuant exploratory laparotomy. J Surg Case Rep. 2016 Jun 1;2016(6). pii:
rjw100. doi: 10.1093/jscr/rjw100. PubMed PMID: 27252520; PubMed Central PMCID:
PMC4888736.
4: Zhang Y, Yang Z, Whitby R, Wang L. Regulation of miR-200c by nuclear receptors
PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):135-9. doi:
10.1016/j.bbrc.2011.11.011. Epub 2011 Nov 11. PubMed PMID: 22100809; PubMed
Central PMCID: PMC3248804.
5: Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA,
Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. Small molecule
agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and
liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14;54(7):2266-81.
doi: 10.1021/jm1014296. Epub 2011 Mar 10. PubMed PMID: 21391689; PubMed Central
PMCID: PMC4151520.
