SS-208 is a potent and selective HDAC6 inhibitor (IC50-12 nM). SS-208 showed Antitumor Activity in Syngeneic Melanoma Mouse Models. SS-208 induces minimal cell death and exhibits marginal effects on viability, cytotoxicity, and apoptosis, while significantly increasing the levels of Ac-α-Tubulin. SS-208 efficiently reduces the IL-6-mediated Y705 phosphorylation of STAT3 and downregulates the expression of PD-L1 at the mRNA levels in melanoma cells
MedKoo Cat#: 408029
Name: SS-208
CAS#: 2245942-72-5
Chemical Formula: C13H11Cl2N3O4
Exact Mass: 343.0127
Molecular Weight: 344.15
Elemental Analysis: C, 45.37; H, 3.22; Cl, 20.60; N, 12.21; O, 18.60
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMSO | 125.0 | 363.21 |
The following data is based on the product molecular weight 344.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
