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MedKoo Cat#: 558733 | Name: BMS-187745

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-187745 is a squalene synthase inhibitor.

Chemical Structure

BMS-187745
BMS-187745
CAS#157126-18-6

Theoretical Analysis

MedKoo Cat#: 558733

Name: BMS-187745

CAS#: 157126-18-6

Chemical Formula: C16H19O7PS

Exact Mass: 386.0589

Molecular Weight: 386.35

Elemental Analysis: C, 49.74; H, 4.96; O, 28.99; P, 8.02; S, 8.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMS187745; BMS 187745 BMS-187745
IUPAC/Chemical Name
(1S)-4-(3-Phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid
InChi Key
RCGCZPXSRLLKCK-INIZCTEOSA-N
InChi Code
InChI=1S/C16H19O7PS/c17-24(18,19)16(25(20,21)22)11-5-7-13-6-4-10-15(12-13)23-14-8-2-1-3-9-14/h1-4,6,8-10,12,16H,5,7,11H2,(H2,17,18,19)(H,20,21,22)/t16-/m0/s1
SMILES Code
O=S([C@H](P(O)(O)=O)CCCC1=CC=CC(OC2=CC=CC=C2)=C1)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sharma A, Slugg PH, Hammett JL, Jusko WJ. Clinical pharmacokinetics and pharmacodynamics of a new squalene synthase inhibitor, BMS-188494, in healthy volunteers. J Clin Pharmacol. 1998 Dec;38(12):1116-21. PubMed PMID: 11301563. 2: Sharma A, Slugg PH, Hammett JL, Jusko WJ. Estimation of oral bioavailability of a long half-life drug in healthy subjects. Pharm Res. 1998 Nov;15(11):1782-6. PubMed PMID: 9834003. 3: Jemal M, Almond R, Ouyang Z, Teitz D. Negative ion electrospray high-performance liquid chromatography-mass spectrometry method development for determination of a highly polar phosphonic acid/sulfonic acid compound in plasma. Optimization of ammonium acetate concentration and in-source collision-induced dissociation. J Chromatogr B Biomed Sci Appl. 1997 Dec 5;703(1-2):167-75. PubMed PMID: 9448073. 4: Flint OP, Masters BA, Gregg RE, Durham SK. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicol Appl Pharmacol. 1997 Jul;145(1):91-8. PubMed PMID: 9221828.