Related CAS #
                                        
                                                                                                                                                                                                        14949-00-9 (free base)
                                                                                                                                                                                        
                                     
                                    
                                        Synonym
                                        Amino thiadiazole sulfonamide, CL 5343 sodium salt, Tio-urasin sodium, Zolamide sodium
                                     
                                    
                                        IUPAC/Chemical Name
                                        1,3,4-Thiadiazole-2-sulfonamide, 5-amino-, monosodium salt
                                     
                                    
                                        InChi Key
                                        QSGOFQPIEHAARI-UHFFFAOYSA-N
                                     
                                    
                                        InChi Code
                                        1S/C2H3N4O2S2.Na/c3-1-5-6-2(9-1)10(4,7)8;/h(H3-,3,4,5,7,8);/q-1;+1
                                     
                                    
                                        SMILES Code
                                        c1(nnc(s1)S(=O)(=O)[NH-])N.[Na+]
                                     
                                    
                                    
                                        Purity
                                        >98% (or refer to the Certificate of Analysis)
                                     
                                    
                                        Shipping Condition
                                        Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
                                     
                                    
                                        Storage Condition
                                        Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
                                     
                                    
                                        Solubility
                                        Soluble in DMSO
                                     
                                    
                                        Shelf Life
                                        >3 years if stored properly
                                     
                                    
                                        Drug Formulation
                                        This drug may be formulated in DMSO
                                     
                                    
                                        Stock Solution Storage
                                        0 - 4 C for short term (days to weeks), or -20 C for long term (months).
                                     
                                    
                                        HS Tariff Code
                                        2934.99.9001
                                     
                                    
                                 
                             
                            
                                                        
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        202.18
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                            
                            
                                
                                    1: Van Berkel MA, Elefritz JL. Evaluating off-label uses of acetazolamide. Am J Health Syst Pharm. 2018 Apr 15;75(8):524-531. doi: 10.2146/ajhp170279. Review. PubMed PMID: 29626002.
2: Arenas-García JI, Herrera-Ruiz D, Morales-Rojas H, Höpfl H. Interrelation of the dissolution behavior and solid-state features of acetazolamide cocrystals. Eur J Pharm Sci. 2017 Jan 1;96:299-308. doi: 10.1016/j.ejps.2016.09.025. Epub 2016 Sep 17. PubMed PMID: 27650458.
3: Llovet-Rausell A, Ruiz Tolosa F, Kudsieh B. Severe ocular side effects with acetazolamide: case report. Arch Soc Esp Oftalmol. 2016 Nov;91(11):543-546. doi:  10.1016/j.oftal.2016.03.013. Epub 2016 May 11. English, Spanish. PubMed PMID: 27179669.
4: Al-Saleem AI, Al-Jobair AM. Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. Drug Des Devel Ther. 2016 Apr 15;10:1471-6. doi: 10.2147/DDDT.S99561. eCollection 2016. PubMed PMID: 27143854; PubMed Central PMCID: PMC4841426.
5: Santoveña A, Suárez-González J, Martín-Rodríguez C, Fariña JB. Formulation design of oral pediatric Acetazolamide suspension: dose uniformity and physico-chemical stability study. Pharm Dev Technol. 2017 Mar;22(2):191-197. doi: 10.1080/10837450.2016.1175475. Epub 2016 Apr 24. PubMed PMID: 27109383.
6: Biondich AS, Joslin JD. Acetazolamide Use in an Ultra-Runner: A Complicated Treatment Consideration for AMS. Wilderness Environ Med. 2016 Mar;27(1):179-80. doi: 10.1016/j.wem.2015.09.001. Epub 2015 Oct 29. PubMed PMID: 26520404.
7: Supuran CT. Acetazolamide for the treatment of idiopathic intracranial hypertension. Expert Rev Neurother. 2015;15(8):851-6. doi: 10.1586/14737175.2015.1066675. Epub 2015 Jul 7. Review. PubMed PMID: 26154918.
8: Falardeau J, Lobb BM, Golden S, Maxfield SD, Tanne E. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol. 2013 Mar;33(1):9-12. doi: 10.1097/WNO.0b013e3182594001. PubMed PMID: 22635167.
9: Kassamali R, Sica DA. Acetazolamide: a forgotten diuretic agent. Cardiol Rev.  2011 Nov-Dec;19(6):276-8. doi: 10.1097/CRD.0b013e31822b4939. Review. PubMed PMID: 21983315.
10: Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9. Review. PubMed PMID: 8740334.