Synonym
007AM; 007 AM; 007-AM; 8 CPT-AM; 8-CPT AM; 8-CPT-AM
IUPAC/Chemical Name
(((4aR,6R,7R,7aR)-6-(6-amino-8-((4-chlorophenyl)thio)-9H-purin-9-yl)-7-methoxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate
InChi Key
FZMWUFYPEVDWPA-SILPBKOMSA-N
InChi Code
InChI=1S/C20H21ClN5O8PS/c1-10(27)30-9-32-35(28)31-7-13-15(34-35)16(29-2)19(33-13)26-18-14(17(22)23-8-24-18)25-20(26)36-12-5-3-11(21)4-6-12/h3-6,8,13,15-16,19H,7,9H2,1-2H3,(H2,22,23,24)/t13-,15-,16-,19-,35?/m1/s1
SMILES Code
NC1=C2C(N([C@@H]3O[C@H](COP(O4)(OCOC(C)=O)=O)[C@@H]4[C@H]3OC)C(SC5=CC=C(Cl)C=C5)=N2)=NC=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
557.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Laudette M, Coluccia A, Sainte-Marie Y, Solari A, Fazal L, Sicard P, Silvestri R, Mialet-Perez J, Pons S, Ghaleh B, Blondeau JP, Lezoualc'h F. Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Mar 14. pii: cvz076. doi: 10.1093/cvr/cvz076. [Epub ahead of print] PubMed PMID: 30873562.
2: Liu Y, Schneider MF. Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres. J Physiol. 2013 Jul 15;591(14):3605-23. doi: 10.1113/jphysiol.2013.256263. Epub 2013 May 7. PubMed PMID: 23652597; PubMed Central PMCID: PMC3731617.
3: Brette F, Blandin E, Simard C, Guinamard R, Sallé L. Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle. J Mol Cell Cardiol. 2013 Apr;57:96-105. doi: 10.1016/j.yjmcc.2013.01.012. Epub 2013 Jan 30. PubMed PMID: 23376036.
4: Chang CW, Chang GD, Chen H. A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion. Mol Cell Biol. 2011 Sep;31(18):3820-31. doi: 10.1128/MCB.05582-11. Epub 2011 Jul 26. PubMed PMID: 21791615; PubMed Central PMCID: PMC3165715.
