Synonym
Rwj 26629; Rwj26629; Rwj-26629
IUPAC/Chemical Name
2-Piperidinone, 1-(6,7-dihydro-6-hydroxy-5,5-dimethyl-2-nitro-5H-thieno(3,2-b)pyran-7-yl)-, cis-(+-)-
InChi Key
QPFLGGHDOFTBOK-AAEUAGOBSA-N
InChi Code
InChI=1S/C14H18N2O5S/c1-14(2)13(18)11(15-6-4-3-5-9(15)17)12-8(21-14)7-10(22-12)16(19)20/h7,11,13,18H,3-6H2,1-2H3/t11-,13-/m0/s1
SMILES Code
O=C1N([C@H]2C3=C(C=C([N+]([O-])=O)S3)OC(C)(C)[C@H]2O)CCCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
326.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Damiano BP, Giardino EC, Haertlein BJ, Stump GL, Mitchell JA, Falotico R. Cardiovascular profile of RWJ 29009, a new potassium channel activator, in anesthetized and conscious dogs. J Cardiovasc Pharmacol. 1994 Feb;23(2):300-10. PubMed PMID: 7511761.
2: Press JB, McNally JJ, Sanfilippo PJ, Addo MF, Loughney D, Giardino E, Katz LB, Falotico R, Haertlein BJ. Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII. Bioorg Med Chem. 1993 Dec;1(6):423-35. PubMed PMID: 8087564.
3: Katz LB, Giardino EC, Salata JJ, Moore JB Jr, Falotico R. RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent. J Pharmacol Exp Ther. 1993 Nov;267(2):648-56. PubMed PMID: 8246137.
4: Damiano BP, Stump GL, Cheung WM, Salata JJ. In vivo cardiac electrophysiologic effects of RWJ 29009, a new potassium-channel activator, in comparison to cromakalim and nicardipine. J Cardiovasc Pharmacol. 1993 Jul;22(1):143-52. PubMed PMID: 7690086.
5: Jacoby HI, Tomko KA, Steffler C, Lee DK. Vasorelaxant effect of the potassium channel activator, RWJ 29009, is tissue selective. Life Sci. 1993;52(21):PL233-8. PubMed PMID: 8502111.
6: Sanfilippo PJ, McNally JJ, Press JB, Fitzpatrick LJ, Urbanski MJ, Katz LB, Giardino E, Falotico R, Salata J, Moore JB Jr, et al. Thiophene systems. 14. Synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxythieno[3,2-b]pyrans and related compounds as new potassium channel activators. J Med Chem. 1992 Nov 13;35(23):4425-33. PubMed PMID: 1447742.
