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MedKoo Cat#: 558694 | Name: 2-HTP
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-HTP is a potent orthosteric and allosteric agonist of GPR84.

Chemical Structure

2-HTP
2-HTP
CAS#376616-73-8

Theoretical Analysis

MedKoo Cat#: 558694

Name: 2-HTP

CAS#: 376616-73-8

Chemical Formula: C10H16N2O2S

Exact Mass: 228.0932

Molecular Weight: 228.31

Elemental Analysis: C, 52.61; H, 7.06; N, 12.27; O, 14.02; S, 14.04

Price and Availability

Size Price Availability Quantity
10mg USD 385.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
2HTP; 2 HTP; 2-HTP; ZQ16; ZQ 16; ZQ-16
IUPAC/Chemical Name
2-(Hexylthio)pyrimidine-4,6 diol
InChi Key
UYXOAKRMLQKLQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
SMILES Code
OC1=NC(SCCCCCC)=NC(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mancini SJ, Mahmud ZA, Jenkins L, Bolognini D, Newman R, Barnes M, Edye ME, McMahon SB, Tobin AB, Milligan G. On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Sci Rep. 2019 Feb 12;9(1):1861. doi: 10.1038/s41598-019-38539-1. PubMed PMID: 30755705; PubMed Central PMCID: PMC6372602. 2: Epe B, Ballmaier D, Adam W, Grimm GN, Saha-Möller CR. Photolysis of N-hydroxpyridinethiones: a new source of hydroxyl radicals for the direct damage of cell-free and cellular DNA. Nucleic Acids Res. 1996 May 1;24(9):1625-31. PubMed PMID: 8649978; PubMed Central PMCID: PMC145837.