PSB-16671 | GPR84 Agonist

MedKoo Cat#: 558693 | Name: PSB-16671

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-16671 is a potent orthosteric and allosteric agonist of GPR84.

Chemical Structure

PSB-16671

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 558693

Name: PSB-16671

CAS#: NONE

Chemical Formula: C17H10F4N2

Exact Mass: 318.0780

Molecular Weight: 318.27

Elemental Analysis: C, 64.15; H, 3.17; F, 23.88; N, 8.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PSB-16671; PSB 16671; PSB16671

IUPAC/Chemical Name

Di(5,7-difluoro-1H-indole-3-yl)methane

InChi Key

VOZFGFKTXNHCLF-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H10F4N2/c18-10-2-12-8(6-22-16(12)14(20)4-10)1-9-7-23-17-13(9)3-11(19)5-15(17)21/h2-7,22-23H,1H2

SMILES Code

FC1=CC(F)=CC2=C1NC=C2CC3=CNC4=C3C=C(F)C=C4F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 318.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mancini SJ, Mahmud ZA, Jenkins L, Bolognini D, Newman R, Barnes M, Edye ME, McMahon SB, Tobin AB, Milligan G. On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Sci Rep. 2019 Feb 12;9(1):1861. doi: 10.1038/s41598-019-38539-1. PubMed PMID: 30755705; PubMed Central PMCID: PMC6372602. 2: Pillaiyar T, Köse M, Sylvester K, Weighardt H, Thimm D, Borges G, Förster I, von Kügelgen I, Müller CE. Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84. J Med Chem. 2017 May 11;60(9):3636-3655. doi: 10.1021/acs.jmedchem.6b01593. Epub 2017 May 1. PubMed PMID: 28406627.