Quilostigmine | CAS#139314-01-5 | cholinergic

MedKoo Cat#: 585069 | Name: Quilostigmine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quilostigmine is a cholinergic.

Chemical Structure

Quilostigmine

CAS#139314-01-5

Theoretical Analysis

MedKoo Cat#: 585069

Name: Quilostigmine

CAS#: 139314-01-5

Chemical Formula: C23H27N3O2

Exact Mass: 377.2103

Molecular Weight: 377.49

Elemental Analysis: C, 73.18; H, 7.21; N, 11.13; O, 8.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Quilostigmine; HP 290; NXX 066; NXX-066

IUPAC/Chemical Name

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)-

InChi Key

IIFRKALDATVOJE-GMAHTHKFSA-N

InChi Code

InChI=1S/C23H27N3O2/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26/h4-9,14,21H,10-13,15H2,1-3H3/t21-,23-/m0/s1

SMILES Code

O=C(N1CC2=C(C=CC=C2)CC1)OC3=CC4=C(N(C)[C@@]5([H])[C@@]4(C)CCN5C)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dahlin M, Björk E. Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int J Pharm. 2001 Jan 16;212(2):267-74. PubMed PMID: 11165084. 2: Sramek JJ, Hourani J, Jhee SS, Cutler NR. NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21. PubMed PMID: 10210264. 3: Snape MF, Misra A, Murray TK, De Souza RJ, Williams JL, Cross AJ, Green AR. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38(1):181-93. PubMed PMID: 10193909. 4: Schmidt S, Martinsson S. In vivo/in vitro microdialysis coupled to capillary LC-LIF. Biomed Chromatogr. 1998 May-Jun;12(3):109-10. PubMed PMID: 9646901. 5: Enlund AM, Schmidt S, Westerlund D. Detectability improvements in capillary zone electrophoresis by combining single capillary isotachophoretic preconcentration and frequency doubled argon ion laser-induced fluorescence detection. Electrophoresis. 1998 May;19(5):707-11. PubMed PMID: 9629903.