MedKoo Cat#: 558678 | Name: IVQ Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IVQ Hydrochloride is a prodrug of QVO, which is quickly converted to QVO in mice and rats following administration. IVQ Hydrochloride also ameliorates hyperglycemia, suppresses hepatic gluconeogenesis and activates AMPK signaling pathway in the liver tissues.

Chemical Structure

IVQ Hydrochloride
IVQ Hydrochloride
CAS#1803533-07-4 (free base)

Theoretical Analysis

MedKoo Cat#: 558678

Name: IVQ Hydrochloride

CAS#: 1803533-07-4 (free base)

Chemical Formula: C19H15ClN2

Exact Mass:

Molecular Weight: 306.79

Elemental Analysis: C, 74.39; H, 4.93; Cl, 11.56; N, 9.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
IVQ Hydrochloride; IVQ HCl
IUPAC/Chemical Name
4-[2-(1H-Indol-3-yl)vinyl]quinoline Hydrochloride
InChi Key
AVOKKBFFNGJTEN-RRABGKBLSA-N
InChi Code
InChI=1S/C19H14N2.ClH/c1-3-7-18-16(5-1)14(11-12-20-18)9-10-15-13-21-19-8-4-2-6-17(15)19;/h1-13,21H;1H/b10-9+;
SMILES Code
[H]Cl.C1(/C=C/C2=CNC3=C2C=CC=C3)=CC=NC4=CC=CC=C14
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 306.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou TT, Zhao T, Ma F, Zhang YN, Jiang J, Ruan Y, Yan QY, Wang GH, Ren J, Guan XW, Guo J, Zhao YH, Ye JM, Hu LH, Chen J, Shen X. Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice. Acta Pharmacol Sin. 2019 Mar 4. doi: 10.1038/s41401-018-0208-2. [Epub ahead of print] PubMed PMID: 30833709.