Synonym
(+/-)-Phthalimidoamlodipine, Amlodipine besilate impurity A , Phthalimidoamlodipine, Phthaloylamlodipine; Phthaloyl Amlodipine
IUPAC/Chemical Name
3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-((2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy)methyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
InChi Key
AHHPZGUFLGCZCF-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H27ClN2O7/c1-4-38-28(35)24-21(15-37-14-13-31-25(32)17-9-5-6-10-18(17)26(31)33)30-16(2)22(27(34)36-3)23(24)19-11-7-8-12-20(19)29/h5-12,23,30H,4,13-15H2,1-3H3
SMILES Code
O=C(C1=C(COCCN(C(C2=C3C=CC=C2)=O)C3=O)NC(C)=C(C(OC)=O)C1C4=CC=CC=C4Cl)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Phthalimidoamlodipine is an impurity of Amlodipine.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
538.98
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gottwald-Hostalek U, Sun N, Barho C, Hildemann S. Management of Hypertension With a Fixed-Dose (Single-Pill) Combination of Bisoprolol and Amlodipine. Clin Pharmacol Drug Dev. 2017 Jan;6(1):9-18. doi: 10.1002/cpdd.309. Epub 2016 Oct 26. PubMed PMID: 27653022.
2: van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. Review. PubMed PMID: 9156957.
Sudhakar, P., Nirmala, M., Babu, J. M., Vyas, K., Reddy, G. M., Bhaskar, B. V., ... & Mukkanti, K. (2006). Identification and characterization of potential impurities of amlodipine maleate. Journal of pharmaceutical and biomedical analysis, 40(3), 605-613.
