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MedKoo Cat#: 585056 | Name: Phaseolin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phaseolin is a protein of red kidney bean (Phaseolus vulgaris L.) and plays a pivotal role in hypersensitivity induction.

Chemical Structure

Phaseolin
Phaseolin
CAS#13401-40-6

Theoretical Analysis

MedKoo Cat#: 585056

Name: Phaseolin

CAS#: 13401-40-6

Chemical Formula: C20H18O4

Exact Mass: 322.1205

Molecular Weight: 322.36

Elemental Analysis: C, 74.52; H, 5.63; O, 19.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Phaseolin
IUPAC/Chemical Name
3H,7H-Furo(3,2-c:5,4-f')bis(1)benzopyran-10-ol, 6b,12b-dihydro-3,3-dimethyl-, (6bR-cis)-
InChi Key
LWTDZKXXJRRKDG-KXBFYZLASA-N
InChi Code
InChI=1S/C20H18O4/c1-20(2)8-7-14-16(24-20)6-5-12-15-10-22-17-9-11(21)3-4-13(17)19(15)23-18(12)14/h3-9,15,19,21H,10H2,1-2H3/t15-,19-/m0/s1
SMILES Code
OC1=CC=C2[C@@](O3)([H])[C@@](C4=C3C5=C(C=C4)OC(C)(C)C=C5)([H])COC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: De Marchis F, Bellucci M, Pompa A. Phaseolin expression in tobacco chloroplast reveals an autoregulatory mechanism in heterologous protein translation. Plant Biotechnol J. 2016 Feb;14(2):603-14. doi: 10.1111/pbi.12405. Epub 2015 Jun 1. PubMed PMID: 26031839. 2: Thibeault J, Church J, Ortiz-Perez B, Addo S, Hill S, Khalil A, Young M, Xia K, Colón W. Analyzing bean extracts using time-dependent SDS trapping to quantify the kinetic stability of phaseolin proteins. Biochem Biophys Res Commun. 2017 Sep 30;491(4):994-999. doi: 10.1016/j.bbrc.2017.07.166. Epub 2017 Aug 1. PubMed PMID: 28774556. 3: Kumar S, Verma AK, Sharma A, Roy R, Kumar D, Bh G, Tripathi A, Chaudhari BP, Das M, Jain SK, Dwivedi PD. Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. Int Immunopharmacol. 2014 Mar;19(1):178-90. doi: 10.1016/j.intimp.2014.01.014. Epub 2014 Jan 24. PubMed PMID: 24468678. 4: de Toledo NM, Rocha LC, da Silva AG, Canniatti Brazaca SG. Interaction and digestibility of phaseolin/polyphenol in the common bean. Food Chem. 2013 Jun 1;138(2-3):776-80. doi: 10.1016/j.foodchem.2012.11.079. Epub 2012 Nov 28. PubMed PMID: 23411175. 5: Montoya CA, Leterme P, Beebe S, Souffrant WB, Mollé D, Lallès JP. Phaseolin type and heat treatment influence the biochemistry of protein digestion in the rat intestine. Br J Nutr. 2008 Mar;99(3):531-9. Epub 2007 Nov 16. PubMed PMID: 18005478. 6: Kunz D, Oliveira GB, Brascher TC, Samuels RI, Macedo MLR, de Souza LF, Dafré AL, Silva CP. Phaseolin ingestion affects vesicular traffic causing oxidative stress in the midgut of Callosobruchus maculatus larvae. Comp Biochem Physiol B Biochem Mol Biol. 2019 Feb;228:34-40. doi: 10.1016/j.cbpb.2018.11.001. Epub 2018 Nov 14. PubMed PMID: 30445225. 7: Venkatachalam M, Sathe SK. Phaseolin in vitro pepsin digestibility: role of acids and phenolic compounds. J Agric Food Chem. 2003 May 21;51(11):3466-72. PubMed PMID: 12744685. 8: Bagga S, Sutton D, Kemp JD, Sengupta-Gopalan C. Constitutive expression of the beta-phaseolin gene in different tissues of transgenic alfalfa does not ensure phaseolin accumulation in non-seed tissue. Plant Mol Biol. 1992 Sep;19(6):951-8. PubMed PMID: 1511140. 9: Montoya CA, Lallès JP, Beebe S, Souffrant WB, Mollé D, Leterme P. Susceptibility of phaseolin (Phaseolus vulgaris) subunits to trypsinolysis and influence of dietary level of raw phaseolin on protein digestion in the small intestine of rats. Br J Nutr. 2009 May;101(9):1324-32. doi: 10.1017/S0007114508060790. Epub 2008 Oct 10. PubMed PMID: 18845022. 10: Kami JA, Gepts P. Phaseolin nucleotide sequence diversity in Phaseolus. I. Intraspecific diversity in Phaseolus vulgaris. Genome. 1994 Oct;37(5):751-7. PubMed PMID: 8001810. 11: Montoya CA, Leterme P, Romé V, Beebe S, Claustre J, Lallès JP. Phaseolin from Phaseolus vulgaris bean modulates gut mucin flow and gene expression in rats. Br J Nutr. 2010 Dec;104(12):1740-7. doi: 10.1017/S0007114510002813. Epub 2010 Aug 2. PubMed PMID: 20673379. 12: Deshpande M, Sathe SK. Interactions with 8-Anilinonaphthalene-1-sulfonic Acid (ANS) and Surface Hydrophobicity of Black Gram (Vigna mungo) Phaseolin. J Food Sci. 2018 Jul;83(7):1847-1855. doi: 10.1111/1750-3841.14204. Epub 2018 Jun 21. PubMed PMID: 29928765. 13: Foresti O, Frigerio L, Holkeri H, de Virgilio M, Vavassori S, Vitale A. A phaseolin domain involved directly in trimer assembly is a determinant for binding by the chaperone BiP. Plant Cell. 2003 Oct;15(10):2464-75. Epub 2003 Sep 24. PubMed PMID: 14508011; PubMed Central PMCID: PMC197309. 14: Diniz AL, Zucchi MI, Santini L, Benchimol-Reis LL, Fungaro MH, Vieira ML. Nucleotide diversity based on phaseolin and iron reductase genes in common bean accessions of different geographical origins. Genome. 2014 Feb;57(2):69-77. doi: 10.1139/gen-2013-0183. Epub 2014 Feb 9. PubMed PMID: 24702064. 15: Castelli S, Vitale A. The phaseolin vacuolar sorting signal promotes transient, strong membrane association and aggregation of the bean storage protein in transgenic tobacco. J Exp Bot. 2005 May;56(415):1379-87. Epub 2005 Apr 4. PubMed PMID: 15809284. 16: Yin SW, Tang CH, Wen QB, Yang XQ. Conformational and thermal properties of phaseolin, the major storage protein of red kidney bean (Phaseolus vulgaris L.). J Sci Food Agric. 2011 Jan 15;91(1):94-9. doi: 10.1002/jsfa.4155. Epub 2010 Sep 2. PubMed PMID: 20815040. 17: Montoya CA, Lallès JP, Beebe S, Montagne L, Souffrant WB, Leterme P. Influence of the Phaseolus vulgaris phaseolin level of incorporation, type and thermal treatment on gut characteristics in rats. Br J Nutr. 2006 Jan;95(1):116-23. PubMed PMID: 16441923. 18: Giosafatto CV, Di Pierro P, Gunning P, Mackie A, Porta R, Mariniello L. Characterization of Citrus pectin edible films containing transglutaminase-modified phaseolin. Carbohydr Polym. 2014 Jun 15;106:200-8. doi: 10.1016/j.carbpol.2014.02.015. Epub 2014 Feb 13. PubMed PMID: 24721069. 19: Carović-Stanko K, Liber Z, Vidak M, Barešić A, Grdiša M, Lazarević B, Šatović Z. Genetic Diversity of Croatian Common Bean Landraces. Front Plant Sci. 2017 Apr 20;8:604. doi: 10.3389/fpls.2017.00604. eCollection 2017. PubMed PMID: 28473842; PubMed Central PMCID: PMC5397504. 20: Frigerio L, de Virgilio M, Prada A, Faoro F, Vitale A. Sorting of phaseolin to the vacuole is saturable and requires a short C-terminal peptide. Plant Cell. 1998 Jun;10(6):1031-42. PubMed PMID: 9634590; PubMed Central PMCID: PMC144029.

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