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MedKoo Cat#: 585055 | Name: Diodone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diodone is an ionic monomeric contrast medium that was formerly used for a variety of diagnostic procedures.

Chemical Structure

Diodone
Diodone
CAS#300-37-8

Theoretical Analysis

MedKoo Cat#: 585055

Name: Diodone

CAS#: 300-37-8

Chemical Formula: C11H16I2N2O5

Exact Mass: 509.9149

Molecular Weight: 510.07

Elemental Analysis: C, 25.90; H, 3.16; I, 49.76; N, 5.49; O, 15.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Diodone, Iodopyracet
IUPAC/Chemical Name
1(4H)-Pyridineacetic acid, 3,5-diiodo-4-oxo-, compd. with 2,2'-iminobis(ethanol) (1:1)
InChi Key
RERHJVNYJKZHLJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H5I2NO3.C4H11NO2/c8-4-1-10(3-6(11)12)2-5(9)7(4)13;6-3-1-5-2-4-7/h1-2H,3H2,(H,11,12);5-7H,1-4H2
SMILES Code
O=C(O)CN(C=C1I)C=C(I)C1=O.OCCNCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Russel FG, Wouterse AC, Van Ginneken CA. Physiologically based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog. Biopharm Drug Dispos. 1989 Mar-Apr;10(2):137-52. PubMed PMID: 2706315. 2: Wang N, Xu Q, Duan S, Lei R, Guo J. [Evaluation of risk factors and prognosis on diodone-induced acute kidney injury according to ESUR and KDIGO criteria]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Jan;41(1):65-70. doi: 10.11817/j.issn.1672-7347.2016.01.010. Chinese. PubMed PMID: 26819427. 3: Burg MB, Weller PF. Iodopyracet transport by isolated perfused flounder proximal renal tubules. Am J Physiol. 1969 Oct;217(4):1053-6. PubMed PMID: 5824304. 4: Hekman P, van Ginneken CA. Kinetic modeling of the renal excretion of iodopyracet in the dog. J Pharmacokinet Biopharm. 1982 Feb;10(1):77-92. PubMed PMID: 7069579. 5: Maher FT, Tauxe WN, Strong CG, Elveback LR. Renal clearance in man of pharmaceuticals containing radioactive iodine: influence of added carrier iodopyracet or o-iodohippurate. Mayo Clin Proc. 1970 Oct;45(10):701-11. PubMed PMID: 5479145. 6: FORBES M, BECKER B. The transport of organic anions by the rabbit eye. II. In vivo transport of iodopyracet (Diodrast). Am J Ophthalmol. 1960 Nov;50:867-75. PubMed PMID: 13700701. 7: Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H. Transport of 99mTc-MAG3 via rat renal organic anion transporter 1. J Nucl Med. 2004 Jan;45(1):80-5. PubMed PMID: 14734677. 8: Katayama K, Ohtani H, Kawabe T, Mizuno H, Endoh M, Kakemi M, Koizumi T. Kinetic studies on drug disposition in rabbits. I. Renal excretion of iodopyracet and sulfamethizole. J Pharmacobiodyn. 1990 Feb;13(2):97-107. PubMed PMID: 2384854. 9: Misson RT, Cutler RE. Radiocontrast-induced renal failure. West J Med. 1985 May;142(5):657-64. PubMed PMID: 4013281; PubMed Central PMCID: PMC1306134. 10: Katayama K, Tsubota E, Endoh M, Kakemi M, Koizumi T. Effect of iodopyracet on renal excretion of sulfamethizole in rabbits. J Pharmacobiodyn. 1990 Mar;13(3):179-85. PubMed PMID: 2374087. 11: Cohen ML. Radionuclide clearance techniques. Semin Nucl Med. 1974 Jan;4(1):23-38. Review. PubMed PMID: 4205000. 12: Reynolds WA, Pitkin RM, Hodari AA. Transfer of radioactive iodopyracet (131-I-Diodrast) from the fetus into amniotic fluid after tracheal ligation. Am J Obstet Gynecol. 1971 Jun 15;110(4):566-71. PubMed PMID: 4996573. 13: SUTHERLAND DL, KITE WC Jr, ROACH JF, CAMPBELL E. A note on the use of 25 per cent iodopyracet (diodrast) in cerebral angiography. J Neurosurg. 1955 May;12(3):223-5. PubMed PMID: 14381929. 14: ALYEA EP, HAINES CE. Intradermal test for sensitivity to iodopyracet injection, or diodrast. J Am Med Assoc. 1947 Sep 6;135(1):25-7. PubMed PMID: 20257747. 15: Wilson DM, Schwartz FD. In vivo incorporation of iodopyracet into erythrocytes of healthy and azotemic patients. J Lab Clin Med. 1968 Dec;72(6):951-7. PubMed PMID: 5723118. 16: PALMER R, PULSFORD J. [Hysterosalpingography with iodopyracet-polyvinylpyrrolidone medium and its association with penicillin perfusion]. Rev Fr Gynecol Obstet. 1954 Jan-Feb;49(1-2):16-22. Undetermined Language. PubMed PMID: 13186513. 17: MANCHESTER PT Jr, BONMATI J. Iodopyracet (diodrast) injection for orbital tumors. AMA Arch Ophthalmol. 1955 Oct;54(4):591-5. PubMed PMID: 13257990. 18: BECKER B, FORBES M. Iodopyracet (diodrast) transport by the rabbit eye. Am J Physiol. 1961 Mar;200:461-4. PubMed PMID: 13688426. 19: Peterson HO. The hazards of myelography. Radiology. 1975 Apr;115(1):237-9. PubMed PMID: 164045. 20: GOLUBOFF B, SHAPIRO B. Use of radioactive iodopyracet in renal function; a preliminary report. J Albert Einstein Med Cent (Phila). 1959 Jan;7(1):16-22. PubMed PMID: 13620429.