Synonym
Ph CL 28A; Ph CL28A; Ph-CL-28-A
IUPAC/Chemical Name
1,3-Benzenedicarboxylic acid, 5-((3-(carboxymethyl)-4-hydroxyphenyl)azo)-, 1,3-dimethyl ester
InChi Key
LNEKRQNMORYHDX-FMQUCBEESA-N
InChi Code
InChI=1S/C18H16N2O7/c1-26-17(24)11-5-12(18(25)27-2)8-14(7-11)20-19-13-3-4-15(21)10(6-13)9-16(22)23/h3-8,21H,9H2,1-2H3,(H,22,23)/b20-19+
SMILES Code
O=C(C1=CC(/N=N/C2=CC=C(O)C(CC(O)=O)=C2)=CC(C(OC)=O)=C1)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
372.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nakamura M, Bakhle YS. Effects of Ph CL 28A on eicosanoid synthesis in rat isolated hearts. Prostaglandins. 1991 Oct;42(4):303-12. PubMed PMID: 1796146.
2: Bakhle YS, Pankhania JJ. Inhibitors of prostaglandin dehydrogenase (Ph CL 28A and Ph CK 61A) increase output of prostaglandins from rat isolated lung. Br J Pharmacol. 1987 Sep;92(1):189-96. PubMed PMID: 3117152; PubMed Central PMCID: PMC1853629.
3: Berry CN, Hoult JR, Phillips JA, McCarthy TM, Agback H. Highly potent inhibition of prostaglandin 15-hydroxydehydrogenase in-vitro and of prostaglandin inactivation in perfused lung by the new azobenzene analogue, Ph CL 28A. J Pharm Pharmacol. 1985 Sep;37(9):622-8. PubMed PMID: 2867182.
4: Santana AC, Hyslop S, Antunes E, De Nucci G, Bakhle YS. Anti-inflammatory activities of Ph CL28A in rats in vivo. Eur J Pharmacol. 1993 Feb 9;231(2):237-42. PubMed PMID: 8384113.
5: Pankhania JJ, Bakhle YS. Treatment in vivo with Ph CL28A alters prostaglandin E2, prostacyclin and leukotriene C4 metabolism in rat isolated lung. Pulm Pharmacol. 1990;3(2):73-7. PubMed PMID: 2135211.
6: Berry CN, Prouteau M, Lloyd KG. Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins? Br J Pharmacol. 1988 Mar;93(3):465-72. PubMed PMID: 2897215; PubMed Central PMCID: PMC1853854.
7: Bakhle YS, Nakamura M, Pankhania JJ. Inhibition of leukotriene C4 output from rat isolated heart and lung by the sulphasalazine derivative Ph CL28A. Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:113-6. PubMed PMID: 1825528.
