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MedKoo Cat#: 585045 | Name: Telocinobufagin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Telocinobufagin is a cardiotonic steroid that inhibits human kidney Na+/K+-ATPase. Telocinobufagin is observed to have anti-cancer effects in various types of tumors.

Chemical Structure

Telocinobufagin
Telocinobufagin
CAS#472-26-4

Theoretical Analysis

MedKoo Cat#: 585045

Name: Telocinobufagin

CAS#: 472-26-4

Chemical Formula: C24H34O5

Exact Mass: 402.2406

Molecular Weight: 402.53

Elemental Analysis: C, 71.61; H, 8.51; O, 19.87

Price and Availability

Size Price Availability Quantity
1mg USD 350.00
5mg USD 600.00
10mg USD 800.00
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Related CAS #
No Data
Synonym
Telocinobufagin; Telobufotoxin
IUPAC/Chemical Name
3beta,5beta,14-trihydroxy-bufa-20,22-dienolide
InChi Key
PBSOJKPTQWWJJD-ZBDZJSKLSA-N
InChi Code
InChI=1S/C24H34O5/c1-21-9-5-16(25)13-23(21,27)11-7-19-18(21)6-10-22(2)17(8-12-24(19,22)28)15-3-4-20(26)29-14-15/h3-4,14,16-19,25,27-28H,5-13H2,1-2H3/t16-,17+,18-,19+,21+,22+,23-,24-/m0/s1
SMILES Code
O=C(C=C1)OC=C1[C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5(O)C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun B, Si N, Wei X, Wang H, Wang H, Liu Y, Jiang S, Liu H, Yang J, Xia B, Chen L, Bian B, Zhao H. Multi-omics reveals bufadienolide Q-markers of Bufonis Venenum based on antitumor activity and cardiovascular toxicity in zebrafish. Phytomedicine. 2024 Oct;133:155914. doi: 10.1016/j.phymed.2024.155914. Epub 2024 Aug 5. PMID: 39121534. 2: Liu Y, Luo Y, Li M, Li Z, Lan J, Lu L, Zhang T, Ding Y. Comparative study on pharmacokinetics of extract from Bufonis venenum and its liposomes. J Pharm Biomed Anal. 2024 Oct 15;249:116375. doi: 10.1016/j.jpba.2024.116375. Epub 2024 Jul 21. PMID: 39083920. 3: Li J, Ma R, Lv JL, Ren YS, Tan YJ, Wang HM, Wang ZE, Wang BS, Yu JN, Wang YL, Tian J, Zheng QS. Telocinobufagin, a PLK1 suppressor that inhibits tumor growth and metastasis by modulating CDC25c and CTCF in HNSCC cells. Phytomedicine. 2024 May;127:155440. doi: 10.1016/j.phymed.2024.155440. Epub 2024 Feb 9. PMID: 38452691. 4: Ye Q, Zhong Z, Chao S, Liu L, Chen M, Feng X, Wu H. Antifungal Effect of Bacillus velezensis ZN-S10 against Plant Pathogen Colletotrichum changpingense and Its Inhibition Mechanism. Int J Mol Sci. 2023 Nov 24;24(23):16694. doi: 10.3390/ijms242316694. PMID: 38069016; PMCID: PMC10705930. 5: Deng YQ, Gao M, Lu D, Liu QP, Zhang RJ, Ye J, Zhao J, Feng ZH, Li QZ, Zhang H. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine. 2024 Jan;123:155169. doi: 10.1016/j.phymed.2023.155169. Epub 2023 Oct 28. PMID: 37992493. 6: Zhao J, Chen X, Zhang H, Liu X, Ma Y, Yao J, Jiang H, Zhou H. Quantification of nine bufadienolides of Shexiang Tongxin Dropping Pills in rat plasma and tissues using UPLC-MS/MS and its application to healthy and ischemia-reperfusion rats pharmacokinetic studies. J Pharm Biomed Anal. 2024 Jan 20;238:115852. doi: 10.1016/j.jpba.2023.115852. Epub 2023 Nov 7. PMID: 37952449. 7: Ma X, Xu W, Jin X, Mu H, Wang Z, Hua Y, Cai Z, Zhang T. Telocinobufagin inhibits osteosarcoma growth and metastasis by inhibiting the JAK2/STAT3 signaling pathway. Eur J Pharmacol. 2023 Mar 5;942:175529. doi: 10.1016/j.ejphar.2023.175529. Epub 2023 Jan 20. PMID: 36690054. 8: Pascual Alonso I, Rivera Méndez L, Almeida García F, Valdés-Tresanco ME, Alonso Bosch R, Perera WH, Arrebola Sánchez Y, Bergado G, Sánchez Ramírez B, Charli JL. Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo-aminopeptidases; relationship with effects on human melanoma MeWo cells. Int J Biol Macromol. 2023 Feb 28;229:825-837. doi: 10.1016/j.ijbiomac.2022.12.280. Epub 2022 Dec 30. PMID: 36592847. 9: Lamichhane S, Mohammed CJ, Haller ST, Kennedy DJ, Isailovic D. Quantification of Cardiotonic Steroids Potentially Regulated by Paraoxonase 3 in a Rat Model of Chronic Kidney Disease Using UHPLC-Orbitrap-MS. Int J Mol Sci. 2022 Nov 5;23(21):13565. doi: 10.3390/ijms232113565. PMID: 36362352; PMCID: PMC9654389. 10: Jia J, Li J, Zheng Q, Li D. A research update on the antitumor effects of active components of Chinese medicine ChanSu. Front Oncol. 2022 Sep 27;12:1014637. doi: 10.3389/fonc.2022.1014637. PMID: 36237327; PMCID: PMC9552564. 11: Wang Z, Wang N, Yang L, Song XQ. Bioactive natural products in COVID-19 therapy. Front Pharmacol. 2022 Aug 19;13:926507. doi: 10.3389/fphar.2022.926507. PMID: 36059994; PMCID: PMC9438897. 12: Li M, Qin Y, Li Z, Lan J, Zhang T, Ding Y. Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS. Front Pharmacol. 2022 Jul 18;13:944041. doi: 10.3389/fphar.2022.944041. PMID: 35928275; PMCID: PMC9343874. 13: Sousa Barros ED, Santos Monção Filho ED, Fonseca Pio YP, Amorim MR, Berlinck RGS, Cássia Moura R, Fonseca MG, Dantas C, Coelho RC, Silva GRD, Chaves MH, Vieira Júnior GM. Comparative study of composition of methanolic extracts of the paratoid gland secretions (PGS) of Rhinella jimi (cururu toad) from northeastern Brazil: Gender, seasonality and geographic occurrence. Toxicon. 2022 Jul 30;214:37-46. doi: 10.1016/j.toxicon.2022.04.020. Epub 2022 May 11. PMID: 35562061. 14: Shen Y, Cai H, Ma S, Zhu W, Zhao H, Li J, Ye H, Yang L, Zhao C, Huang X, Xiao Z. Telocinobufagin Has Antitumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3 Signaling. J Nat Prod. 2022 Apr 22;85(4):765-775. doi: 10.1021/acs.jnatprod.1c00761. Epub 2022 Feb 24. PMID: 35200033. 15: Jin YH, Jeon S, Lee J, Kim S, Jang MS, Park CM, Song JH, Kim HR, Kwon S. Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections. Pharmaceutics. 2021 Nov 2;13(11):1839. doi: 10.3390/pharmaceutics13111839. PMID: 34834252; PMCID: PMC8618917. 16: Gao Y, Shi L, Cao Z, Zhu X, Li F, Wang R, Xu J, Zhong J, Zhang B, Lu S. Erratum: Telocinobufagin inhibits the epithelial-to-mesenchymal transition of breast cancer cells through the PI3K/Akt/Snail signaling pathway. Oncol Lett. 2021 Apr;21(4):242. doi: 10.3892/ol.2021.12503. Epub 2021 Jan 31. Erratum for: Oncol Lett. 2018 May;15(5):7837-7845. doi: 10.3892/ol.2018.8349. PMID: 33664806; PMCID: PMC7882880. 17: Oliveira RS, Borges BT, Leal AP, de Brum Vieira P, Silva DB, Hyslop S, Vinadé L, Dos Santos TG, Carlini CR, Orchard I, Lange AB, Dal Belo CA. Chemical and functional analyses of Rhinella icterica (Spix, 1824) toad secretion screened on contractions of the heart and oviduct in Locusta migratoria. J Insect Physiol. 2021 Feb-Mar;129:104192. doi: 10.1016/j.jinsphys.2021.104192. Epub 2021 Jan 16. PMID: 33460706. 18: Liu P, Yang P, Zhang L. Mode of Action of Shan-Zhu-Yu (Cornus officinalis Sieb. et Zucc.) in the Treatment of Depression Based on Network Pharmacology. Evid Based Complement Alternat Med. 2020 Nov 22;2020:8838888. doi: 10.1155/2020/8838888. PMID: 33299459; PMCID: PMC7704135. 19: Yu P, Ma J, Du Y, Wang Q, Chen C, Bai X, He L, Zou D. An efficient strategy based on liquid-liquid extraction and pH-zone-refining counter-current chromatography for selective enrichment, separation, and purification of alkaloids and organic Acids from natural products. J Sep Sci. 2020 Sep;43(18):3607-3614. doi: 10.1002/jssc.202000528. Epub 2020 Aug 4. PMID: 32678501. 20: Oliveira RS, Borges BT, Leal AP, Lailowski MM, Bordon KCF, Souza VQ, Vinadé L, Santos TGD, Hyslop S, Moura S, Arantes EC, Corrado AP, Dal Belo CA. Chemical and Pharmacological Screening of Rhinella icterica (Spix 1824) Toad Parotoid Secretion in Avian Preparations. Toxins (Basel). 2020 Jun 15;12(6):396. doi: 10.3390/toxins12060396. PMID: 32549266; PMCID: PMC7354542.