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MedKoo Cat#: 573767 | Name: AM-112

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AM-112 is an Oxapenem compound which possesses potent beta-lactamase-inhibitory properties.

Chemical Structure

AM-112
AM-112
CAS#414858-51-8

Theoretical Analysis

MedKoo Cat#: 573767

Name: AM-112

CAS#: 414858-51-8

Chemical Formula: C14H22N2O5

Exact Mass: 298.1529

Molecular Weight: 298.34

Elemental Analysis: C, 56.36; H, 7.43; N, 9.39; O, 26.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AM-112, AM112, AM 112
IUPAC/Chemical Name
4-Oxa-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(4-amino-1,1-dimethylbutyl)-6-((1R)-1-hydroxyethyl)-7-oxo-, (5R,6R)-
InChi Key
MJNFEDQKHJZAEX-RGNHYFCHSA-N
InChi Code
1S/C14H22N2O5/c1-7(17)8-11(18)16-9(13(19)20)10(21-12(8)16)14(2,3)5-4-6-15/h7-8,12,17H,4-6,15H2,1-3H3,(H,19,20)/t7-,8+,12-/m1/s1
SMILES Code
C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(O2)C(C)(C)CCCN)C(=O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 298.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bowker KE, Noel AR, Walsh TR, Rogers CA, MacGowan AP. Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamases. Antimicrob Agents Chemother. 2004 Nov;48(11):4482-4. PubMed PMID: 15504890; PubMed Central PMCID: PMC525393. 2: Simpson IN, Urch CJ, Hagen G, Albrecht R, Sprinkart B, Pfaendler HR. Synthesis and biological activity of AM-112 and related oxapenem analogues. J Antibiot (Tokyo). 2003 Oct;56(10):838-47. PubMed PMID: 14700277. 3: Jamieson CE, Lambert PA, Simpson IN. In vitro and in vivo activities of AM-112, a novel oxapenem. Antimicrob Agents Chemother. 2003 May;47(5):1652-7. PubMed PMID: 12709336; PubMed Central PMCID: PMC153311.