CD2019 | CAS#143984-56-9 | (RARbeta) agonist

MedKoo Cat#: 565728 | Name: CD2019

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.

Chemical Structure

CD2019

CAS#143984-56-9

Theoretical Analysis

MedKoo Cat#: 565728

Name: CD2019

CAS#: 143984-56-9

Chemical Formula: C25H26O3

Exact Mass: 374.1882

Molecular Weight: 374.48

Elemental Analysis: C, 80.18; H, 7.00; O, 12.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CD2019; CD 2019; CD-2019

IUPAC/Chemical Name

6-(4-Methoxy-3-(1-methylcyclohexyl)phenyl)-2-naphthoic acid

InChi Key

SWIWERVMTLKNLQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26O3/c1-25(12-4-3-5-13-25)22-16-20(10-11-23(22)28-2)18-6-7-19-15-21(24(26)27)9-8-17(19)14-18/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,26,27)

SMILES Code

O=C(O)C1=CC=C2C=C(C3=CC=C(OC)C(C4(C)CCCCC4)=C3)C=CC2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Agudo M, Yip P, Davies M, Bradbury E, Doherty P, McMahon S, Maden M, Corcoran JP. A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiol Dis. 2010 Jan;37(1):147-55. doi: 10.1016/j.nbd.2009.09.018. Epub 2009 Oct 2. PubMed PMID: 19800972; PubMed Central PMCID: PMC2789321. 2: Gianni M, Zanotta S, Terao M, Garattini S, Garattini E. Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells. Biochem Biophys Res Commun. 1993 Oct 15;196(1):252-9. PubMed PMID: 8216300. 3: Falanga A, Consonni R, Marchetti M, Locatelli G, Garattini E, Passerini CG, Gordon SG, Barbui T. Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood. 1998 Jul 1;92(1):143-51. PubMed PMID: 9639510. 4: Jiang SY, Lin DY, Shyu RY, Reichert U, Yeh MY. The RARgamma selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis. Cancer Lett. 1999 Apr 1;137(2):217-25. PubMed PMID: 10374844. 5: Arafa HM, Elmazar MM, Hamada FM, Reichert U, Shroot B, Nau H. Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure. Arch Toxicol. 2000 Jan;73(10-11):547-56. PubMed PMID: 10663386. 6: Lampen A, Meyer S, Nau H. Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells. Drug Metab Dispos. 2001 May;29(5):742-7. PubMed PMID: 11302942. 7: Nuka S, Sawada N, Iba K, Chiba H, Ishii S, Mori M. All-trans retinoic acid inhibits dexamethasone-induced ALP activity and mineralization in human osteoblastic cell line SV HFO. Cell Struct Funct. 1997 Feb;22(1):27-32. PubMed PMID: 9113387. 8: Million K, Tournier F, Houcine O, Ancian P, Reichert U, Marano F. Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation. Am J Respir Cell Mol Biol. 2001 Dec;25(6):744-50. PubMed PMID: 11726401. 9: Worm M, Krah JM, Manz RA, Henz BM. Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro. Blood. 1998 Sep 1;92(5):1713-20. PubMed PMID: 9716600. 10: Arafa HM, Hamada FM, Elmazar MM, Nau H. Fully automated determination of selective retinoic acid receptor ligands in mouse plasma and tissue by reversed-phase liquid chromatography coupled on-line with solid-phase extraction. J Chromatogr A. 1996 Apr 5;729(1-2):125-36. PubMed PMID: 9004933. 11: Meister B, Fink FM, Hittmair A, Marth C, Widschwendter M. Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma. Anticancer Res. 1998 May-Jun;18(3A):1777-86. PubMed PMID: 9673404. 12: Boisvieux-Ulrich E, Le Pechon-Vallée C, Million K, Baeza-Squiban A, Houcine O, Guennou C, Reichert U, Marano F. Differential effects of several retinoid receptor-selective ligands on squamous differentiation and apoptosis in airway epithelial cells. Cell Tissue Res. 2000 Apr;300(1):67-81. PubMed PMID: 10805076.