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MedKoo Cat#: 565721 | Name: BI-D (ALLINI)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI-D (ALLINI) is a novel potent allosteric integrase inhibitor (allini), inhibiting hiv replication

Chemical Structure

BI-D (ALLINI)
BI-D (ALLINI)
CAS#1416258-16-6

Theoretical Analysis

MedKoo Cat#: 565721

Name: BI-D (ALLINI)

CAS#: 1416258-16-6

Chemical Formula: C25H27NO4

Exact Mass: 405.1940

Molecular Weight: 405.49

Elemental Analysis: C, 74.05; H, 6.71; N, 3.45; O, 15.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BI-D; BI D; BID
IUPAC/Chemical Name
[4-(3,4-Dihydro-2H-chromen-6-yl)-2-methyl-3-quinolinyl][(2-methyl-2-propanyl)oxy]acetic acid
InChi Key
ZFERZAMPQIXCPM-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27NO4/c1-15-21(23(24(27)28)30-25(2,3)4)22(18-9-5-6-10-19(18)26-15)17-11-12-20-16(14-17)8-7-13-29-20/h5-6,9-12,14,23H,7-8,13H2,1-4H3,(H,27,28)
SMILES Code
O=C(O)C(C1=C(C2=CC(CCCO3)=C3C=C2)C4=CC=CC=C4N=C1C)OC(C)(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. PubMed PMID: 25421939; PubMed Central PMCID: PMC4251946. 2: van Bel N, van der Velden Y, Bonnard D, Le Rouzic E, Das AT, Benarous R, Berkhout B. The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome. PLoS One. 2014 Jul 29;9(7):e103552. doi: 10.1371/journal.pone.0103552. eCollection 2014. PubMed PMID: 25072705; PubMed Central PMCID: PMC4114784. 3: Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. PubMed PMID: 26910179; PubMed Central PMCID: PMC4874862.