Authipyrin | CAS#N/A | autophagy inhibitor

MedKoo Cat#: 565702 | Name: Authipyrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Authipyrin is a novel autophagy inhibitor, targeting mitochondrial complex i directly, leading to the potent inhibition of mitochondrial respiration as well as autophagy

Chemical Structure

Authipyrin

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565702

Name: Authipyrin

CAS#: N/A

Chemical Formula: C20H19N3O3S

Exact Mass: 381.1147

Molecular Weight: 381.45

Elemental Analysis: C, 62.98; H, 5.02; N, 11.02; O, 12.58; S, 8.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

Authipyrin

Synonym

1049722-30-6

IUPAC/Chemical Name

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(1-(thieno[2,3-d]pyrimidin-4-yl)piperidin-4-yl)methanone

InChi Key

UJJCDSDROQBQQE-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H19N3O3S/c24-18(14-1-2-16-17(11-14)26-9-8-25-16)13-3-6-23(7-4-13)19-15-5-10-27-20(15)22-12-21-19/h1-2,5,10-13H,3-4,6-9H2

SMILES Code

O=C(C1=CC=C2OCCOC2=C1)C3CCN(C4=C(C=CS5)C5=NC=N4)CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 381.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kaiser N, Corkery D, Wu Y, Laraia L, Waldmann H. Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin. Bioorg Med Chem. 2019 Jun 15;27(12):2444-2448. doi: 10.1016/j.bmc.2019.02.028. Epub 2019 Feb 16. PubMed PMID: 30795990.